- MIV-818/LENVATINIB COMBINATION THERAPY FOR LIVER CANCER
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Use of lenvatinib, or a pharmaceutically acceptable salt thereof in combination with a compound of the formula MIV-818: (MIV-818) or pharmaceutically acceptable salt thereof, in the treatment of liver cancer or liver metastases. The respective dosage regimes of the compounds can be delivered concurrently or alternately.
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Page/Page column 14
(2021/10/22)
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- Troxacitabine synthesis and crystalline forms
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The present invention provides a troxacitabine synthesis method and troxacitabine crystallization methods. Further, the present invention also provides troxacitabine crystalline forms and application.
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Paragraph 0058; 0059; 0060; 0061
(2016/10/27)
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- DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER
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The invention provides compounds of formula (I), wherein: R1 is OR11, or NR5R5'; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(=O)R6, O(C=O)R6 or O(C=O)OR6; R5′ is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
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Page/Page column 32
(2016/03/22)
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- Structure-activity relationships among a new class of antiviral heterosubstituted 2',3'-dideoxynucleoside analogues
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3'-Oxa-4'-thiocytidine nucleoside analogues 14-17 were prepared from oxathiolanes 10 and 11, and evaluated for activity against HIV-1 and HBV in vitro. The nucleoside analogues were found to possess potent activities against HIV-1 in a panel of cell lines. Compound 16 is moderately active against HBV in 2.2.15 cells.
- Mansour,Jin,Wang,Dixit,Evans,Tse,Belleau,Gillard,Hooker,Ashman,Cammack,Salomon,Belmonte,Wainberg
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p. 627 - 635
(2007/10/02)
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- L-β-(2S,4S)- and L-α-(2S,4R)-dioxolanyl nucleosides as potential anti- HIV agents: Asymmetric synthesis and structure-activity relationships
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In order to study the structure-activity relationships of L-(2S,4S)- and L-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents, various enantiomerically pure L-(2S,4S)- and (2S,4R)-dioxolanylpyrimidine and - purine nucleosides have been synthesize
- Kim,Schinazi,Shanmuganathan,Jeong,Beach,Nampalli,Cannon,Chu
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p. 519 - 528
(2007/10/02)
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- Oxidative Degradation of L-Ascorbic Acid Acetals to 2',3'-Dideoxy-3'-Oxaribofuranosides. Synthesis of Enantiomerically Pure 2',3'-Dideoxy-3'-Oxacytidine Stereoisomers as Potential Antiviral Agents
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Enantiomerically pure 2',3'-dideoxy-3'-oxacytidine nucleoside analogues were synthesized from L-ascorbic acid in eight steps and good overall yield.
- Belleau, Bernard R.,Evans, Colleen A.,Tse, H. L. Allan,Jin, Haolun,Dixit, Dilip M.,Mansour, Tarek S.
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p. 6949 - 6952
(2007/10/02)
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- Potent Anti-HIV and Anti-HBV Activities of (-)-L-&β-Dioxolane-C and (+)-L-&β-Dioxolane-T and Their Asymmetric Syntheses.
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The asymmetric syntheses of (+)-L-β-dioxolane-T and (-)-L-β-dioxolane-C were accomplished starting from 1,6-anhydro-L-β-gulopyranose, and their anti-HIV and anti-HBV activities were evaluated in human PBM cells, CEM cells and 2.2.15 cells, respectively. K
- Kim, Hea O.,Shanmuganathan, Kirupathevy,Alves, Antonio J.,Jeong, Lak S.,Beach, J. Warren,et al.
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p. 6899 - 6902
(2007/10/02)
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