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1-Hydroxy Pioglitazone Hydrochloride is a pharmaceutical compound derived from the thiazolidinedione class of drugs, which are known for their insulin-sensitizing properties. It is characterized by its ability to modulate cellular pathways and exhibit neuroprotective effects, making it a promising candidate for the treatment of various central nervous system (CNS) disorders.

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  • 146062-46-6 Structure
  • Basic information

    1. Product Name: 1-Hydroxy Pioglitazone Hydrochloride
    2. Synonyms: 1-Hydroxy Pioglitazone Hydrochloride;5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione:hydrochloride
    3. CAS NO:146062-46-6
    4. Molecular Formula: C19H21ClN2O4S
    5. Molecular Weight: 408.89904
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 146062-46-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-Hydroxy Pioglitazone Hydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-Hydroxy Pioglitazone Hydrochloride(146062-46-6)
    11. EPA Substance Registry System: 1-Hydroxy Pioglitazone Hydrochloride(146062-46-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 146062-46-6(Hazardous Substances Data)

146062-46-6 Usage

Uses

Used in Pharmaceutical Industry:
1-Hydroxy Pioglitazone Hydrochloride is used as a therapeutic agent for the treatment of CNS disorders. Its application is based on its ability to act as an inhibitor of D-amino acid oxidase and D-aspartate oxidase, which are enzymes involved in the metabolism of D-amino acids. By inhibiting these enzymes, 1-Hydroxy Pioglitazone Hydrochloride can help regulate the levels of D-amino acids in the brain, which may contribute to the alleviation of CNS disorder symptoms.
Additionally, 1-Hydroxy Pioglitazone Hydrochloride has been shown to possess neuroprotective properties, which can be beneficial in the treatment of neurodegenerative diseases and other conditions affecting the CNS. Its use in the pharmaceutical industry is focused on developing novel treatments for a range of CNS disorders, leveraging its unique mechanisms of action to improve patient outcomes.

Check Digit Verification of cas no

The CAS Registry Mumber 146062-46-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,0,6 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 146062-46:
(8*1)+(7*4)+(6*6)+(5*0)+(4*6)+(3*2)+(2*4)+(1*6)=116
116 % 10 = 6
So 146062-46-6 is a valid CAS Registry Number.

146062-46-6Upstream product

146062-46-6Downstream Products

146062-46-6Relevant articles and documents

Thiazolidinedione derivatives, production and use thereof

-

, (2008/06/13)

A thiazolidinedione compound of the formula STR1 wherein X,Q are as defined in the specification. The compounds are used for treating diabetes.

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