146426-54-2Relevant articles and documents
Chimeric (α-amino acid + nucleoside-β-amino acid)n peptide oligomers show sequence specific DNA/RNA recognition
Gogoi, Khirud,Kumar, Vaijayanti A.
, p. 706 - 708 (2008)
An α/β-peptide backbone oligonucleotide comprising natural α-amino acids alternating with a β-amino acid component derived from thymidine sequence specifically recognizes and binds to deoxy- and ribo-oligoadenylates in triplex mode. The Royal Society of Chemistry.
An Entry of the Chemoselective Sulfo-Click Reaction into the Sphere of Nucleic Acids
Clavé, Guillaume,Dursun, Enes,Smietana, Michael,Vasseur, Jean-Jacques
, (2020)
We report here the first example of a sulfo-click conjugation reaction to be applied to modified nucleosides. The reaction, which proceeds rapidly (k ~2.0 × 10-1 M-1 s-1 at 25 °C) under aqueous biocompatible conditions in
Ruthenium tetraoxide catalyzed oxidation of nucleosides: A facile synthesis of 5'-carboxylic acid derivatives
Varma,Hogan
, p. 7719 - 7720 (1992)
Purine and pyrimidine nucleosides have been oxidized to the corresponding 5'-carboxylic acids using potassium persulfate and ruthenium trichloride under basic conditions. The method provides easy access to nucleosides bearing 3'-amino and 5'-carboxylic acid functionalities from 3'-azido compounds as exemplified by oxidation of AZT followed by reduction of the acid.
Nucleoside derived amino acids (NDA) in foldamer chemistry: synthesis and conformational studies of homooligomers of modified AZT
Chandrasekhar,Pavan Kumar Reddy,Udaya Kiran,Nagesh,Jagadeesh
, p. 2969 - 2973 (2008)
Homo short-oligomers of a novel trans-β-amino acid derived from AZT were synthesized and characterized. These adopt right-handed helical turns with their bases positioned systematically along the helix axis. These studies open up new possibilities for synthesizing nucleoside derived functional foldamers.
Novel helical foldamers: Organized heterogeneous backbone folding in 1:1 α/nucleoside-derived-β-amino acid sequences
Chandrasekhar, Srivari,Kiranmai, Nayani,Kiran, Marelli Udaya,Devi, Ambure Sharada,Reddy, Gangireddy Pavan Kumar,Idris, Mohammed,Jagadeesh, Bharatam
supporting information; experimental part, p. 6962 - 6964 (2010/11/03)
Secondary structural conformation of hybrid oligo-peptides comprised of 1:1 alternating Nucleoside Derived β-Amino acid (NDA) and l-amino acid residues has been reported. The studies reveal that the NDA residues organize the heterogeneous backbone featuri
Synthesis of aminodisaccharide-nucleoside conjugates for RNA binding
Cai, Li,Li, Qin,Ren, Bo,Yang, Zhen-Jun,Zhang, Liang-Ren,Zhang, Li-He
, p. 8135 - 8144 (2008/02/08)
Two types of aminodisaccharide-nucleoside conjugates were synthesized by the condensation of azidodisaccharide and nucleoside using aliphatic diamine as a linker. The corresponding azidodisaccharides could be yielded from neamine in good yield. The bindin
Synthesis of DNA analogues with novel carboxamidomethyl phosphonamide and glycinamide internucleoside linkages
Efimov,Buryakova,Chakhmakhcheva
, p. 1013 - 1018 (2007/10/03)
Thymidine oligonucleotide analogues with phosphodiester bonds fully substituted by carboxamidomethyl phosphonamide, or glycinamide linkages were synthesized on a solid support, and their hybridization properties toward DNA and RNA targets were determined by Tm analysis.