- SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B
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Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed. Such diseases include, without limitation, neurological dysfunction such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, and seizure disorders; emotional disorders; depression; bipolar disorder; obsessive-compulsive disorder; and other anxiety disorders.
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Paragraph 0166
(2015/04/15)
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- SUBSTITUTED N-BICYCLICALKYL BICYCLIC CARBOXYAMIDE COMPOUNDS
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This invention provides a compound of the formula (I): And their use for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This invention also provides a pharmaceutical composition compri
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Page/Page column 38
(2008/06/13)
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- ANALYTE DETECTION
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The present invention relates to sensitive SE(R)RS based methods for detecting analytes such as explosives and drugs, which may be present in a sample at extremely low levels. The methods may be generally carried out in situ employing novel chemistry whic
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- Substituted Aryloxymethyl Bicyclicmethyl Acetamide Compounds
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This invention provides a compound of the formula (I): wherein A=B=D represents NR10—C(O)—NR9, S—C(O)—NR9, NR9—C(O)—S, NR9—C(O)—O, CR10—C(O)—NR9, O—C(O)—NR9, NR10
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Page/Page column 29
(2008/06/13)
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