- Synthesis of Some New Acetanilide Derivatives as COX Inhibitors and Assessment of Analgesic/Anti-Inflammatory Activities
-
The purpose of the present research was to synthesize a new series of acetanilide derivatives that would have analgesic and anti-inflammatory properties in laboratory animals (rats). IR spectroscopy, 1HNMR spectroscopy and Mass spectroscopy wer
- Kumar, Arvind,Mishra, Arun K.,Singh, Rajib Kumar
-
p. 1475 - 1487
(2022/01/24)
-
- A synthetic method for diclofenac zinc
-
The invention relates to a synthetic method for diclofenac zinc, and belongs to the field of chemical synthesis of medicines. Aniline is adopted as a raw material and is reacted with 2,6-dichlorophenol under the action of acetyl chloride to obtain 2-(2,6-dichlorophenoxy)-N-phenylacetamide; the 2-(2,6-dichlorophenoxy)-N-phenylacetamide is adopted to prepare N-(2,6-dichlorophenyl)phenylamine under action of an inorganic alkali; the N-(2,6-dichlorophenyl)phenylamine is subjected to a cyclization reaction under the action of chloroacetyl chloride to prepare 1-(2,6-dichlorophenyl)-2-indolone; and the 1-(2,6-dichlorophenyl)-2-indolone is subjected to hydrolysis, and other reactions to synthesize the diclofenac zinc. According to the method, the cost is low, the yield is high, the total yield is 70%, reaction conditions are mild particularly, the method is environment-friendly, and waste gas generated in a reaction process, such as hydrogen chloride, is absorbed by an absorbing system, and therefore the method has a good industrialization prospect.
- -
-
Paragraph 0021; 0037-0039
(2017/07/21)
-