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146667-84-7

3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester, also known as Tert-butyl 3-(2-hydroxyethyl)piperidine-1-carboxylate, is a chemical compound that serves as a key intermediate in the synthesis of pharmaceuticals and agrochemicals. It is characterized by its tert-butyl ester derivative structure of a piperidine carboxylic acid with an additional hydroxyl ethyl group, which endows it with unique structural properties and potential biological activity.

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  • 146667-84-7 Structure

  • Basic information

    1. Product Name: 3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester
    2. Synonyms: 3-(2-HYDROXY-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-PIPERIDINE-3-ETHANOL;1-BOC-3-(2-HYDROXY-ETHYL)-PIPERIDINE;TERT-BUTYL 3-(2-HYDROXYETHYL)PIPERIDINE-1-CARBOXYLATE;1-Boc-piperidine-3-ethanol;1-Boc-3-hydroxyethyl piperidine;1-N-Boc-piperidine-3-ethanol ,98%;N-Boc-3-(2-hydroxyethyl)piperidine
    3. CAS NO:146667-84-7
    4. Molecular Formula: C12H23NO3
    5. Molecular Weight: 229.32
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 146667-84-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 324.066 °C at 760 mmHg
    3. Flash Point: 149.79 °C
    4. Appearance: /
    5. Density: 1.043 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.479
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 15.09±0.10(Predicted)
    11. CAS DataBase Reference: 3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
    12. NIST Chemistry Reference: 3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester(146667-84-7)
    13. EPA Substance Registry System: 3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester(146667-84-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 146667-84-7(Hazardous Substances Data)

146667-84-7 Usage

Uses

Used in Pharmaceutical Industry:
3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester is used as a key intermediate in the synthesis of new drugs and active pharmaceutical ingredients. Its unique structural properties and potential biological activity make it a valuable component in the development of innovative medications.
Used in Agrochemical Industry:
3-(2-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester is also utilized in the production of pesticides and other agricultural products. Its chemical properties allow it to be incorporated into formulations that can enhance crop protection and yield.

Check Digit Verification of cas no

The CAS Registry Mumber 146667-84-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,6,6 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 146667-84:
(8*1)+(7*4)+(6*6)+(5*6)+(4*6)+(3*7)+(2*8)+(1*4)=167
167 % 10 = 7
So 146667-84-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H23NO3/c1-12(2,3)16-11(15)13-7-4-5-10(9-13)6-8-14/h10,14H,4-9H2,1-3H3

146667-84-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-Butyl 3-(2-hydroxyethyl)piperidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names tert-butyl 3-(2-hydroxyethyl)piperidine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:146667-84-7 SDS

146667-84-7Relevant articles and documents

Beta lactam compounds and their use as inhibitors of tryptase

-

Page column 257, (2010/11/29)

Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.

CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.

Wacker, Dean A,Santella 3rd., Joseph B,Gardner, Daniel S,Varnes, Jeffrey G,Estrella, Melissa,DeLucca, George V,Ko, Soo S,Tanabe, Keiichi,Watson, Paul S,Welch, Patricia K,Covington, Maryanne,Stowell, Nicole C,Wadman, Eric A,Davies, Paul,Solomon, Kimberly A,Newton, Robert C,Trainor, George L,Friedman, Steven M,Decicco, Carl P,Duncia, John V

, p. 1785 - 1789 (2007/10/03)

CCR3 antagonist leads with IC(50) values in the microM range were converted into low nM binding compounds that displayed in vitro inhibition of human eosinophil chemotaxis induced by human eotaxin. In particular, 4-benzylpiperidin-1-yl-n-propylureas and erythro-3-(4-benzyl-2-(alpha-hydroxyalkyl)piperidin-1-yl)-n-propylureas (obtained via Beak reaction of N-BOC-4-benzylpiperidine) exhibited single digit nanomolar IC(50) values for CCR3.

Synthesis of 3-Vinylpiperidine

Lowen, Gregory T.,Almond, Merrick R.,Rideout, Janet L.

, p. 1663 - 1665 (2007/10/02)

A novel synthesis of 3-vinylpiperidine from commercially available ethyl 3-pyridylacetate is described.

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