Novel one-pot method for chemoselective bromination and sequential sonogashira coupling
(Equation Presented). An efficient one-pot method for bromination- elimination of allyl alcohol derivatives and sequential Sonogashira coupling has been developed. A highlight of the method is chemoselective DBU-promoted elimination of vicinal dibromoalka
Kutsumura, Noriki,Niwa, Kentaro,Saito, Takao
supporting information; experimental part
p. 3316 - 3319
(2010/10/19)
Efficient synthesis of propargylic ethers under the DBU conditions and its application to natural products synthesis
Conversion of dibromides carrying O-functional groups at adjacent positions to the corresponding propargylic ethers was successfully carried out under the DBU conditions through 2-bromo-1-alkenes as intermediates. The optically active γ-lactone-class natural products, such as (-)-muricatacin (4) and (R,R)-sapinofuranone B (5) were synthesized using the propargylic ether intermediate produced by the elimination reaction mentioned above.