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146709-78-6

5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE, also known as ZD 7155 Hydrochloride, is a chemical compound with a complex molecular structure. It is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor, which plays a crucial role in regulating blood pressure and fluid balance in the body.

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  • 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE

    Cas No: 146709-78-6

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  • 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE

    Cas No: 146709-78-6

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  • 5,7-diethyl-1-[(2'-(1h-tetrazol-5-yl)biphenyl-4yl)methyl] -1,2,3,4-tetrahydro-1,6-naphthyridin-2-one Hydrochloride

    Cas No: 146709-78-6

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  • 146709-78-6 Structure

  • Basic information

    1. Product Name: 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE
    2. Synonyms: ZD 7155 HYDROCHLORIDE;5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE;5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride;ZD7155HCl
    3. CAS NO:146709-78-6
    4. Molecular Formula: C26H26N6O*ClH
    5. Molecular Weight: 474.99
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 146709-78-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 746.4°Cat760mmHg
    3. Flash Point: 405.2°C
    4. Appearance: /
    5. Density: g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: Desiccate at +4°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE(146709-78-6)
    11. EPA Substance Registry System: 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE(146709-78-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 146709-78-6(Hazardous Substances Data)

146709-78-6 Usage

Uses

Used in Pharmaceutical Industry:
5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE is used as a therapeutic agent for treating hypertension and other cardiovascular diseases. It acts as a selective competitive antagonist for the angiotensin II type 1 (AT1) receptor, effectively blocking the action of angiotensin II, a potent vasoconstrictor, and leading to a reduction in blood pressure.
Used in Research Applications:
In the field of medical research, 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE is utilized as a research tool to study the role of angiotensin II and its receptors in various physiological and pathological processes. 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE helps researchers understand the underlying mechanisms of hypertension, heart failure, and other related conditions, ultimately contributing to the development of novel therapeutic strategies.
Used in Drug Development:
5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE serves as a lead compound in the development of new drugs targeting the angiotensin II type 1 (AT1) receptor. Its potent and selective antagonistic properties make it an attractive candidate for further optimization and modification to improve its pharmacokinetic and pharmacodynamic properties, potentially leading to the discovery of more effective and safer antihypertensive medications.

Biological Activity

A potent and selective competitive antagonist for the angiotensin II type 1 (AT 1 ) receptor. Displaces [ 125 I]-angiotensin II binding with an IC 50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT 1 antagonist, losartan.

Check Digit Verification of cas no

The CAS Registry Mumber 146709-78-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,7,0 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 146709-78:
(8*1)+(7*4)+(6*6)+(5*7)+(4*0)+(3*9)+(2*7)+(1*8)=156
156 % 10 = 6
So 146709-78-6 is a valid CAS Registry Number.

146709-78-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,7-diethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4yl)methyl] -1,2,3,4-tetrahydro-1,6-naphthyridin-2-one hydrochloride

1.2 Other means of identification

Product number -
Other names ZD 7155

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:146709-78-6 SDS

146709-78-6Downstream Products

146709-78-6Relevant articles and documents

1,6-NAPHTHYRIDONE DERIVATIVES HAVING ANGIOTENSIN II ANTAGONIST ACTIVITY

-

, (2008/06/13)

The invention concerns pharmaceutically useful compounds of the formula I, in which R 1, R 2, R 3, R 4, Ra, Rb, A, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

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