Aldol Reactions of Ketone Donors with Aryl Trifluoromethyl Ketone Acceptors Catalyzed by 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) for Concise Access to Aryl- and Trifluoromethyl- Substituted Tertiary Alcohols
Molecules bearing aryl- and trifluoromethyl-substituted tertiary alcohol moieties are important as bioactive molecules, enantiomer-discriminating reagents, and their synthons and building blocks. To concisely synthesize these molecules, we have developed
Direct aldol reaction of trifluoromethyl ketones with ketones catalyzed by Et2Zn and secondary amines
The direct catalytic aldol reaction of trifluoromethyl ketones with ketones has been accomplished. The reaction was achieved in the presence of 10 mol% Et2Zn and N,N-dimethylethylenediamine at ambient temperature to give the expected aldol-type
KETONE-KETONE CONDENSATION WITH THE PARTICIPATION OF POLYHALOALKYL PHENYL KETONES
In the cross condensation of polyhaloalkyl phenyl ketones with methyl ketones in the presence of (ethylphenylamino)magnesium or (diethylamino)magnesium bromide or lithium hydride β-hydroxy ketones are formed, and the dehydration of these under the action
Sosnovskikh, V. Ya.,Ovsyannikov, I. S.,Aleksandrova, I. A.
p. 420 - 426
(2007/10/02)
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