Cyclometalated iridium complexes as highly active catalysts for the hydrogenation of imines
A robust cyclometalated iridium catalyst has been developed for highly effective hydrogenation of imines. With very low catalyst loading (down to 0.005%), good to excellent yields have been achieved for a range of substrates in a short reaction time under
Iridium-Catalyzed Acid-Assisted Hydrogenation of Oximes to Hydroxylamines
We found that cyclometalated cyclopentadienyl iridium(III) complexes are uniquely efficient catalysts in homogeneous hydrogenation of oximes to hydroxylamine products. A stable iridium C,N-chelation is crucial, with alkoxy-substituted aryl ketimine ligand
Cope, Christopher J.,Cramer, Nicolai,Mas-Roselló, Josep,Pinson, Benjamin,Robinson, Alan,Smejkal, Tomas,Tan, Eric
supporting information
p. 15524 - 15532
(2021/06/11)
CATALYST COMPOUNDS
The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.
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Paragraph 0331; 0333; 0334; 0335; 0336
(2015/03/28)
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