Stereoselective synthesis of azetidine-derived glutamate and aspartate analogues from chiral azetidin-3-ones
The stereoselective syntheses of cis conformationally constrained glutamate and aspartate analogues, containing an azetidine framework were accomplished from (S)-N-tosyl-2-phenylglycine in moderate overall yields. The key steps in these syntheses involved
Burtoloso, Antonio Carlos B.,Correia, Carlos Roque D.
experimental part
p. 9928 - 9936
(2009/04/03)
Stereospecific synthesis of azetidine-cis-2,3-dicarboxylic acid
Electrocyclic reaction product of 1-(methoxycarbonyl)-1,2-dihydropyridine was stereospecifically converted by RuO4 oxidation into azetidine-cis-2,3-dicarboxylic acid.
Azetidine derivatives to treat memory and learning disorders
This invention relates to novel azetidines and derivatives thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and composi
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(2008/06/13)
Azetidine derivatives, compositions and methods of treating
This invention relates to novel azetidines and derivative thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and compositions as biological tools and materials for characterizing excitatory amino acid receptor systems. A further aspect of the invention relates to a method of treating PCP toxicity and abuse.
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(2008/06/13)
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