Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists
Through preparation and examination of a series of novel 4-amino-2-phenylpyrimidine derivatives as agonists for GPR119, we identified 2-(4-bromophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine (9t). Compound 9t improved glucose tolerance in mice following oral administration and showed good pharmacokinetic profiles in rats.
Heterocyclic amplifiers of phleomycin. VII. Phenyl-, tolyl-, phenoxy- and benzyl-pyrimidines; also some carbocyclic analogues
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Brown,Cronin,Lan,Nardo
p. 825 - 833
(2007/10/02)
Benzoxazolyl-stilbenes
Benzoxazolyl-stilbenes of the formula STR1 in which R is a 6-membered heterocyclic radical which has 2 nitrogen atoms in the o-position, m-position or p-position relative to one another, and one of Z and Zo is hydrogen and the other is hydrogen or chlorine, and the benzene nucleus A can carry conventional non-chromophoric substituents, processes for their preparation and their use for the fluorescent brightening of organic material.
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(2008/06/13)
Studies on ketene and its derivatives. XXXV. Synthesis of 2-substituted-6-methyl-4(3H)-pyrimidone from beta-aminocrotonamide and ethyl carboxylate
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Kato,Yamanaka,Konno
p. 509 - 511
(2007/10/04)
Reactions with imide acid esters. VI. Transformation of imide acid esters with beta-amino crotonic acid ester
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Ried,Stock
p. 87 - 91
(2007/10/04)
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