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4'-METHYLBIPHENYL-3-CARBOXYLIC ACID is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 147404-69-1 Structure
  • Basic information

    1. Product Name: 4'-METHYLBIPHENYL-3-CARBOXYLIC ACID
    2. Synonyms: RARECHEM AL BE 1348;AKOS BAR-0001;4'-METHYL[1,1'-BIPHENYL]-3-CARBOXYLIC ACID;4'-METHYLBIPHENYL-3-CARBOXYLIC ACID;4'-METHYL-3-BIPHENYLCARBOXYLIC ACID;3-(4-METHYLPHENYL)BENZOIC ACID;CHEMBRDG-BB 4400410;3-(4-Tolyl)benzoic acid
    3. CAS NO:147404-69-1
    4. Molecular Formula: C14H12O2
    5. Molecular Weight: 212.24
    6. EINECS: N/A
    7. Product Categories: pharmacetical;Carboxylic Acids;Biphenyl & Diphenyl ether;Carboxylic Acids;Ring Systems
    8. Mol File: 147404-69-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 399.4 °C at 760 mmHg
    3. Flash Point: 182 °C
    4. Appearance: /
    5. Density: 1.156 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 4.14±0.10(Predicted)
    10. CAS DataBase Reference: 4'-METHYLBIPHENYL-3-CARBOXYLIC ACID(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4'-METHYLBIPHENYL-3-CARBOXYLIC ACID(147404-69-1)
    12. EPA Substance Registry System: 4'-METHYLBIPHENYL-3-CARBOXYLIC ACID(147404-69-1)
  • Safety Data

    1. Hazard Codes: Xi,Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 147404-69-1(Hazardous Substances Data)

147404-69-1 Usage

Uses

4''-Methylbiphenyl-3-carboxylic acid

Check Digit Verification of cas no

The CAS Registry Mumber 147404-69-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,4,0 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 147404-69:
(8*1)+(7*4)+(6*7)+(5*4)+(4*0)+(3*4)+(2*6)+(1*9)=131
131 % 10 = 1
So 147404-69-1 is a valid CAS Registry Number.

147404-69-1 Well-known Company Product Price

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  • Alfa Aesar

  • (H51769)  4'-Methylbiphenyl-3-carboxylic acid, 95%   

  • 147404-69-1

  • 1g

  • 536.0CNY

  • Detail
  • Alfa Aesar

  • (H51769)  4'-Methylbiphenyl-3-carboxylic acid, 95%   

  • 147404-69-1

  • 5g

  • 2117.0CNY

  • Detail

147404-69-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(4-methylphenyl)benzoic acid

1.2 Other means of identification

Product number -
Other names 4'-Methyl-biphenyl-3-carbonsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:147404-69-1 SDS

147404-69-1Relevant articles and documents

Green synthesis of biphenyl carboxylic acids via Suzuki–Miyaura cross-coupling catalyzed by a water-soluble fullerene-supported PdCl2 nanocatalyst

Liu, Wanyun,Zhou, Xiuming,Huo, Ping,Li, Jingbo,Mei, Guangquan

, p. 50 - 52 (2019/06/21)

A green synthesis of variously substituted biphenyl carboxylic acids was achieved through Suzuki–Miyaura cross-coupling of a bromobenzoic acid with an aryl boronic acid using a water-soluble fullerene-supported PdCl2 nanocatalyst (C60-TEGs/ PdCl2). Yields of more than 90% were obtained at room temperature in 4 h using 0.05 mol% catalyst and 2 equiv. K2CO3.

1,5-disubstituted tetrazole compounds, and preparation method and application thereof

-

, (2018/03/24)

The invention discloses 1,5-disubstituted tetrazole compounds, and a preparation method and an application thereof. The 1,5-disubstituted tetrazole compounds have good antitumor activity. The invention also provides a use of the 1,5-disubstituted tetrazol

NOVEL SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1

-

Page/Page column 25-26, (2017/02/09)

The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and the use thereof to prevent age-induced skin structure and function defects.

New telmisartan-derived PPARγ agonists: Impact of the 3D-binding mode on the pharmacological profile

Obermoser, Victoria,Urban, Margarethe E.,Murgueitio, Manuela S.,Wolber, Gerhard,Kintscher, Ulrich,Gust, Ronald

supporting information, p. 138 - 152 (2016/08/30)

In previous studies, the 4′-((2-propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-carboxylic acid was identified as pharmacophoric core for PPARγ activation. In this structure-activity relationship study the C2-alkyl chain was elongated and the 2-COOH group was changed to a carbamide/carbonitrile or shifted to the 3- or 4-position. Furthermore, the benzo[d]imidazole was exchanged by 2,3-dihydrobenzo[d]thiazole or 1H-indole. C2-propyl derivatives showed the profile of partial agonists, while elongation of the C2-chain to that of an n-heptyl group or a 4-COOH shift changed the pharmacological profile to that of a potent full agonist. This finding can be explained by binding to the LBD in different ligand conformations. Two anchoring points (Tyr473 and Arg288) exist in the LBD, which have to be contacted to achieve receptor activation. In a crystal violet chemosensitivity assay using COS-7?cells and LNCaP cells expressing PPARγ only the carbamide derivatives influenced the cell growth, independently on the presence of the PPARγ. Therefore, receptor mediated cytotoxicity can be excluded.

Melamine and melamine-formaldehyde polymers as ligands for palladium and application to Suzuki-Miyaura cross-coupling reactions in sustainable solvents

Edwards, Grant A.,Trafford, Mitchell A.,Hamilton, Alaina E.,Buxton, Audrey M.,Bardeaux, Matthew C.,Chalker, Justin M.

, p. 2094 - 2104 (2014/04/03)

The Suzuki-Miyaura cross-coupling reaction is a foundation stone of modern organic synthesis, as evidenced by its widespread use in the preparation of pharmaceuticals, agrochemicals, polymers, and other functional materials. With the prevalence of this venerable reaction in industrial synthesis, it is prudent to ensure its application adheres to the tenets of green chemistry. The introduction of cross-coupling catalysts that are active in sustainable solvents is therefore an important endeavor. In this report, a melamine-palladium complex is introduced as a versatile catalyst for the Suzuki-Miyaura cross-coupling reaction. This catalyst is soluble and active in both water and the renewable organic solvent ethyl lactate. The melamine-palladium catalyst can also be cross-linked by reaction with formaldehyde to generate an insoluble polymeric catalyst that can be recovered after the cross-coupling. The melamine-palladium system is inexpensive, easy to handle, bench-stable, and effective in catalysis in the presence of a variety of impurities (high cross-coupling yields were obtained in reactions run in unfiltered river water to illustrate this final point). Additionally, investigations reported herein revealed an intriguing relationship between catalytic efficiency and the base employed in the cross-coupling reaction. Implications for the mechanism of transmetalation in aqueous Suzuki-Miyaura cross-coupling reaction are discussed.

A highly efficient catalyst of a nitrogen-based ligand for the Suzuki coupling reaction at room temperature under air in neat water

Liu, Shiwen,Lv, Meiyun,Xiao, Daoan,Li, Xiaogang,Zhou, Xiuling,Guo, Mengping

supporting information, p. 4511 - 4516 (2014/06/23)

Glycine, as a kind of commercially available and inexpensive ligand, is used to prepare an air-stable and water-soluble catalyst for the Suzuki-Miyaura reaction in our study. In the presence of 0.1% [PdCl2(NH 2CH2COOH)2] as the catalyst, extremely excellent catalytic activity towards the Suzuki-Miyaura coupling of aryl halides containing the carboxyl group with various aryl boronic acids is observed at room temperature under air in neat water. the Partner Organisations 2014.

Suzuki-miyaura cross-coupling under solvent-free conditions

Asachenko, Andrey F.,Sorochkina, Kristina R.,Dzhevakov, Pavel B.,Topchiy, Maxim A.,Nechaev, Mikhail S.

, p. 3553 - 3557 (2014/01/06)

A solvent-free reaction protocol for Suzuki-Miyaura cross-couplings was developed. (Hetero)aryl bromides and chlorides are coupled with pinacol arylboronates in high yields. The reaction is catalyzed by conventional bis(triphenylphosphine)palladium(II) chloride [(PPh3) 2PdCl2] and/or palladium(II) acetate/SPhos [Pd(OAc) 2/SPhos] under air. Copyright

Synthesis and functionalization of cyclic sulfonimidamides: A novel chiral heterocyclic carboxylic acid bioisostere

Pemberton, Nils,Graden, Henrik,Evertsson, Emma,Bratt, Emma,Lepistoe, Matti,Johannesson, Petra,Svensson, Per H.

supporting information; experimental part, p. 574 - 578 (2012/08/29)

An efficient synthesis of aryl substituted cyclic sulfonimidamides designed as chiral nonplanar heterocyclic carboxylic acid bioisosteres is described. The cyclic sulfonimidamide ring system could be prepared in two steps from a trifluoroacetyl protected sulfinamide and methyl ester protected amino acids. By varying the amino acid, a range of different C-3 substituted sulfonimidamides could be prepared. The compounds could be further derivatized in the aryl ring using standard cross-coupling reactions to yield highly substituted cyclic sulfonimidamides in excellent yields. The physicochemical properties of the final compounds were examined and compared to those of the corresponding carboxylic acid and tetrazole derivatives. The unique nonplanar shape in combination with the relatively strong acidity (pKa 5-6) and the ease of modifying the chemical structure to fine-tune the physicochemical properties suggest that this heterocycle can be a valuable addition to the range of available carboxylic acid isosteres.

Suzuki-Miyaura coupling reactions in aqueous microdroplets with catalytically active fluorous interfaces

Theberge, Ashleigh B.,Whyte, Graeme,Frenzel, Max,Fidalgo, Luis M.,Wootton, Robert C. R.,Huck, Wilhelm T. S.

supporting information; experimental part, p. 6225 - 6227 (2010/02/16)

Using microfluidic techniques and a novel fluorous-tagged palladium catalyst, we generated droplet reactors with catalytically active walls and used these compartments for small molecule synthesis.

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