147441-52-9

Basic information

• Product Name: (2S)-2-(4-bromophenyl)-1,3-oxathiolane
• CAS NO: 147441-52-9
• Molecular Formula: C₉H₉BrOS
• Molecular Weight: 245.1362
• Mol File: 147441-52-9.mol

Chemical Properties

• Boiling Point: 339.1°C at 760 mmHg
• Flash Point: 158.9°C
• Density: 1.535g/cm³
• Vapor Pressure: 0.000185mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: (2S)-2-(4-bromophenyl)-1,3-oxathiolane(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-(4-bromophenyl)-1,3-oxathiolane(147441-52-9)
• EPA Substance Registry System: (2S)-2-(4-bromophenyl)-1,3-oxathiolane(147441-52-9)

Safety Data

• Hazardous Substances Data: 147441-52-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
(2S)-2-(4-bromophenyl)-1,3-oxathiolane is utilized as a key intermediate in the synthesis of various pharmaceutical agents. Its unique structure allows it to target specific biological pathways, making it a valuable component in drug development.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (2S)-2-(4-bromophenyl)-1,3-oxathiolane serves as a building block for designing new molecules with therapeutic potential. Its versatility in chemical modifications contributes to the creation of diverse drug candidates for treating various diseases and conditions.

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 60-24-2 2-hydroxyethanethiol 

Downstream Products

• 1122-91-4 4-bromo-benzaldehyde 
• 876156-57-9 2-(4-bromophenyl)-3-trifluoromethyl-1,4-oxathiinane-3-carboxylic acid methyl ester 
• 876156-57-9 2-(4-bromophenyl)-3-trifluoromethyl-1,4-oxathiinane-3-carboxylic acid methyl ester 
• 83521-65-7 2-(4-bromophenyl)-1,3-dithiolane 
• 1186296-22-9 dibenzyl (2R)-2-(4-bromophenyl)-1,4-oxathiane-3,3-dicarboxylate 
• 873-75-6 4-bromobenzenemethanol 

Relevant articles and documents

Blue LED-Promoted Oxathiacetalization of Aldehydes and Ketones

In synthetic chemistry, the protection of aldehydes and ketones is crucial during multistep synthesis of complex molecules. Organic chemists have paid substantial attention to the synthesis of 1,3-oxathiolanes and 1,3-oxathianes because of their considera

Visible light photoredox catalyzed deprotection of 1,3-oxathiolanes

An efficient visible light photoredox catalyzed aerobic deprotection of 1,3-oxathiolanes using organic dye Eosin Y as a photocatalyst is disclosed. The deprotection procedure features the use of a metal-free catalyst, mild conditions, a broad range of substrate scope, and good functional group tolerance. 35 examples were tested under the standard conditions and most of them afforded the deprotected products in modest to high yields.

Nickel(II) chloride hexahydrate catalyzed reaction of aromatic aldehydes with 2-mercaptoethanol: Formation of supramolecular helical assemblage of the product

Various aromatic aldehydes on reaction with 2-mercaptoethanol provided an unanticipated product, bis(2-hydroxyethyl)dithioacetals (3) as the major product along with the expected product 1,3-oxathiolanes (4) in the presence of 0.05 equiv amount of nickel(

An efficient method for the oxathioacetalization of carbonyl compounds using N-bromosaccharin as a catalyst

A mild and highly chemoselective method for the preparation of oxathiolane from aliphatic and aromatic aldehydes and ketones with 2-mercaptoethanol in the presence of catalytic amount of N-bromosaccharin at room temperature is reported.

Silica gel-supported polyphosphoric acid (PPA/SiO2) as an efficient and reusable catalyst for conversion of carbonyl compounds into oxathioacetals and dithioacetals

A simple and efficient method for the conversion of carbonyl compounds to oxathioacetals and dithioacetals by using polyphosphoric acid supported on silica gel (PPA/SiO2) as an acid catalyst have been developed. PPA/SiO2 is easily re

Scandium(III) Triflate as an Efficient and Recyclable Catalyst for Chemoselective Conversion of Carbonyl Compounds to 1,3-Oxathiolanes

A variety of carbonyl compounds can be easily and rapidly converted to the corresponding 1,3-oxathiolanes in the presence of a catalytic amount of scandium(III) triflate [Sc(OTf)3] in CH2Cl2. After completion of the reacti