147849-82-9

Basic information

• Product Name: 6-(tert-butyl)pyridazin-3(2H)-one
• Synonyms: 6-(tert-butyl)pyridazin-3(2H)-one;6-tert-butyl-2,3-dihydropyridazin-3-one
• CAS NO: 147849-82-9
• Molecular Formula: C8H12N2O
• Molecular Weight: 152.19
• Mol File: 147849-82-9.mol

Chemical Properties

• Appearance: /
• Density: 1.07±0.1 g/cm3(Predicted)
• PKA: 11.51±0.40(Predicted)
• CAS DataBase Reference: 6-(tert-butyl)pyridazin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(tert-butyl)pyridazin-3(2H)-one(147849-82-9)
• EPA Substance Registry System: 6-(tert-butyl)pyridazin-3(2H)-one(147849-82-9)

Safety Data

• Hazardous Substances Data: 147849-82-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
6-(tert-butyl)pyridazin-3(2H)-one is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile chemical reactions, facilitating the synthesis of a wide range of compounds.
Used in Coordination Chemistry:
In coordination chemistry, 6-(tert-butyl)pyridazin-3(2H)-one is employed as a ligand. Its ability to form stable complexes with metal ions makes it a valuable component in the development of new coordination compounds with potential applications in catalysis, materials science, and other areas.
Used in Pharmaceutical Research:
6-(tert-butyl)pyridazin-3(2H)-one may have potential pharmaceutical applications, although further research is required to understand its properties and potential uses fully. Its unique structure and functional groups could contribute to the development of new drugs or drug candidates in the pharmaceutical industry.
Used in Research and Development:
6-(tert-butyl)pyridazin-3(2H)-one is utilized in research and development for exploring its chemical properties, reactivity, and potential applications in various fields. Its study can lead to the discovery of new reactions, compounds, and technologies that benefit multiple industries.

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 298-12-4 Glyoxilic acid 
• 1046816-36-7 6-tert-butyl-4,5-dihydropyridazin-3(2H)-one 

Downstream Products

• 1086383-74-5 3-bromo-6-tert-butylpyridazine 
• 41144-46-1 3-chloro-6-(1,1-dimethylethyl)pyridazine 

Relevant articles and documents

Bulk Inclusions of Double Pyridazine Molecular Rotors in Hexagonal Tris(o-phenylene)cyclotriphosphazene

A new generation of double pyridazine molecular rotors differing in intramolecular dipole-dipole spacing was synthesized. All rotor molecules formed bulk inclusions in a tris(o-phenylenedioxy)cyclotriphosphazene (TPP) host. Results of dielectric spectroscopy were fitted to a pair of nine-state models that accounted for interactions of neighboring dipoles at either an aligned or opposed possible orientation of the local threefold dipole rotation potentials within a channel of the TPP host. The results indicate dipole-dipole interaction strengths at the 100 to 200 K scale that lead dipoles to preferentially populate a subset of low-energy configurations. They also reveal that pyridazines with ethynyl substituents in 3- and 6-positions have slightly higher rotational barriers (3.2-3.5 kcal/mol) than those carrying one ethynyl and one tert-butyl group (1.9-3.0 kcal/mol). Upon cooling, these barriers reduce the rate of thermal transitions between the potential wells so much that the inclusions cannot achieve ordered dipolar ground states.

COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.

Endothelin receptor antagonists

This invention relates to pyridizinone derivatives of formula I STR1 wherein the various substituents are defined in the specification, and salts thereof, which have useful pharmacological properties, in particular endothelin receptor-antagonistic properties. The compounds are thus useful for the treatment of illnesses associated with endothelin activities, such as hypertension, cardiac insufficiency, coronary heart disease, renal, cerebral and myocardial ischaemia, renal insufficiency, cerebral infarct, subarachnoid haemorrhage, arteriosclerosis pulmonary high blood pressure, inflammations, asthma, prostate hyperplasia, endotoxic shock and in complications after the administration of immunosuppressants which produce renal vasoconstriction.

One-pot preparation of 6-substituted 3(2H)-pyridazinones from ketones

A one-pot process for the preparation of 6-phenyl-3(2H)-pyridazinone from acetophenone and glyoxylic acid has been investigated and shown to have wide utility in the preparation of 6- and 5,6-substituted 3(2H)-pyridazinones. Limitations to the process encountered with 2'-hydroxyacetophenone and with basic hetero-aromatic ketones have been overcome, and the processes described offer the rapid and efficient synthesis of many 6-substituted pyridazinones from readily available ketones.