148619-41-4 Usage
Uses
Used in Pharmaceutical Industry:
Ternatin heptapeptide is used as an antifungal agent for its ability to inhibit fungal growth, which can be beneficial in treating various fungal infections.
Used in Cosmetics Industry:
Ternatin heptapeptide is used as an active ingredient in anti-obesity and weight management products for its potent inhibitory effects on fat accumulation in adipocytes.
Used in Research and Development:
Ternatin heptapeptide is used as a research tool for studying the mechanisms of fat accumulation and the development of new treatments for obesity and related metabolic disorders.
Used in Drug Delivery Systems:
Similar to gallotannin, Ternatin heptapeptide can be incorporated into novel drug delivery systems to enhance its applications and efficacy against specific health conditions, such as obesity or fungal infections. Various organic and metallic nanoparticles can be employed as carriers for Ternatin heptapeptide delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 148619-41-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,6,1 and 9 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 148619-41:
(8*1)+(7*4)+(6*8)+(5*6)+(4*1)+(3*9)+(2*4)+(1*1)=154
154 % 10 = 4
So 148619-41-4 is a valid CAS Registry Number.
InChI:InChI=1/C37H67N7O8/c1-16-22(8)28-37(52)43(14)25(11)35(50)44(15)27(18-20(4)5)32(47)38-26(17-19(2)3)36(51)42(13)24(10)34(49)41(12)23(9)31(46)40-29(33(48)39-28)30(45)21(6)7/h19-30,45H,16-18H2,1-15H3,(H,38,47)(H,39,48)(H,40,46)
148619-41-4Relevant articles and documents
Convergent synthesis and in vivo inhibitory effect on fat accumulation of (-)-ternatin, a highly N-methylated cyclic peptide
Shimokawa, Kenichiro,Yamada, Kaoru,Kita, Masaki,Uemura, Daisuke
, p. 4447 - 4449 (2007)
(-)-Ternatin (1), a highly N-methylated cyclic heptapeptide, is a potent inhibitor of fat accumulation against 3T3-L1 murine adipocytes (EC50 = 0.14 μg/mL) [Shimokawa, K.; Mashima, I.; Asai, A.; Yamada, K.; Kita, M.; Uemura, D. Tetrahedron Lett. 2006, 47, 4445]. Compound 1 was synthesized from Boc-protected amino acids in solution. Upon treatment with 1 at 5 mg/kg/day, increases in body weight and fat accumulation in high-fat-fed mice were both significantly suppressed.
(-)-Ternatin, a highly N-methylated cyclic heptapeptide that inhibits fat accumulation: structure and synthesis
Shimokawa, Kenichiro,Mashima, Itsuka,Asai, Akiko,Yamada, Kaoru,Kita, Masaki,Uemura, Daisuke
, p. 4445 - 4448 (2007/10/03)
A highly N-methylated cyclic heptapeptide, (-)-ternatin, was isolated from the mushroom Coriolus versicolor, which significantly suppressed fat accumulation against 3T3-L1 murine adipocytes (EC50 = 0.14 μg/mL). Although ternatin was previously
