Phenethylamines via Heck Arylation of a New Vinylamine Equivalent
A new vinylamine equivalent, N-vinyloxazolone 3, has been prepared in three steps and shown to undergo Heck arylation with a variety of substrates.The Heck adducts thus obtained are then converted in one step and high yield to phenethylamine hydrochlorides.As a general synthetic method for preparation of substituted phenethylamines, use of this new reagent is shown to be superior to N-vinylphthalimide in number of steps, regiospecificity, and chemical yield.
Busacca, Carl A.,Johnson, Robert E.,Swestock, John
p. 3299 - 3303
(2007/10/02)
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