148796-51-4Relevant articles and documents
Efficient syntheses, human and yeast farnesyl-protein transferase inhibitory activities of chaetomellic acids and analogues
Singh, Sheo B.,Jayasuriya, Hiranthi,Silverman, Keith C.,Bonfiglio, Cynthia A.,Williamson, Joanne M.,Lingham, Russell B.
, p. 571 - 580 (2007/10/03)
Chaetomellic acids are a class of alkyl dicarboxylic acids that were isolated from Chaetomella acutiseta. They are potent and highly specific farnesyl-pyrophosphate (FPP) mimic inhibitors of Ras farnesyl-protein transferase. We have previously described t
Synthesis of chaetomellic acid A: A potent inhibitor of Ras farnesyl-protein transferase
Singh, Sheo B.
, p. 6521 - 6524 (2007/10/02)
Chaetomellic acids are alkyl dicarboxylic acids, isolated from Chaetomella acutiseta and are potent and highly specific farnesyl-pyrophosphate (FPP) mimic inhibitors of Ras farnesyl-protein transferase. The first efficient and biogenetic type total synthe