- Peroxynitrite ion detection probe as well as preparation method and application thereof
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The invention provides a peroxynitrite ion detection probe. The molecular formula of the peroxynitrite ion detection probe AH-1 is C20H15NO2. The invention further discloses a preparation method and application of the peroxynitrite ion detection probe. The molecular structure of the peroxynitrite ion detection probe provided by the invention comprises a 9,10-dihydracridine (DHAC) response unit; the probe does not have fluorescent light; when the probe reacts with peroxynitrite ions, a fluorescent product can be produced; furthermore, the detection process has the characteristics of quick response, sensitivity and high selectivity; meanwhile, the probe is easy to synthesize and modify and extremely high in biocompatibility and can be used for detecting intrinsic type peroxynitrite ions in a biological system.
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Paragraph 0044; 0046; 0049; 0050; 0051
(2017/07/21)
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- Process for preparing n-alkylanilines and n-allylanilines
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The present invention relates to a process for the n-alkylation and n-allylation of anilines by bringing the aniline into contact with an alkylating or allylating agent in an organic solvent in a homogeneous liquid phase in the presence of an onium ion and a stoichiometric amount of a non-quaternizable base.
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- Selective ortho-chlorination of phenols
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Phenolic compounds, notably admixtures of 2,4-dichlorophenol and 2,6-dichlorophenol, are selectively chlorinated at the ortho positions thereof, with gaseous chlorine and in a molten medium, in the presence of a selectivity-enhancing effective amount of an organic cation.
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- Selective chlorination of ortho-substituted phenols
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Ortho-substituted phenolic compounds, e.g., 2,6-dichlorophenol, are selectively chlorinated, e.g., into 2,4,6-trichlorophenol, with gaseous chlorine in either the molten state or in a solvent medium, in the presence of a selectivity-enhancing effective amount of an organic cation.
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- Preparation of Ortho-Substituted Benzoic Acids by the Copper(II)-Catalyzed Reaction of Diphenyliodonium-2-carboxylate with Anilines and Other Nucleophiles
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Diphenyliodonium-2-carboxylate (DPIC) reacts readily in copper ion catalyzed condensations with a variety of nucleophiles to give ortho-substituted benzoic acids.These reactions occur at temperatures (80-100 deg C) below those at which benzyne formation and other side reactions become important.The nature of the Cu(II) catalysis appears to be different from the more common Cu(I) catalysis of diaryliodonium reactions in that high specificity in the displacement reaction is retained.Products obtained directly from DPIC condensations include N-anthranilic acid (5b), N-methyl-N-phenylanthranilic acid (5c), N-mesyl-N-(2,3-dimethylphenyl)anthranilic acid (5d), N-(3-chloro-2-methylphenyl)-N-tosylanthranilic acid (5e), and o-(2,3-dimethylphenoxy)benzoic acid (5f).Compound 5d has been cyclized to N-(2,3-dimethylphenyl)-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide (6).
- Scherrer, Robert A.,Beatty, Helga R.
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p. 2127 - 2131
(2007/10/02)
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