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148892-91-5

5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM, also known as Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate (GMP-PNP, Gpp(NH)p), is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. It is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM is often used in studies of protein synthesis. It is also used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis, and other metabolic processes.

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  • 148892-91-5 Structure

  • Basic information

    1. Product Name: 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM
    2. Synonyms: 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM;guanosine 5'-[β,γ-imido]triphosphate trisodium salt;β:γ-imidoguanosine 5'-triphosphate trisodium salt;5μ-Guanylyl-imidodiphosphate hydrate trisodium salt, GMP-PNP, Gpp(NH)p, β:γ-Imidoguanosine 5μ-triphosphate hydrate trisodium salt;Guanosine 5μ-[β,γ-imido]triphosphate hydrate trisodium salt;5′-Guanylyl-imidodiphosphate trisodium salt hydrate;Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate;β:γ-Imidoguanosine 5′-triphosphate trisodium salt hydrate
    3. CAS NO:148892-91-5
    4. Molecular Formula: C10H13N6Na3O10P2
    5. Molecular Weight: 508.161252
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 148892-91-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: white/powder
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: −70°C
    8. Solubility: H2O: 50 mg/mL
    9. CAS DataBase Reference: 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM(148892-91-5)
    11. EPA Substance Registry System: 5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM(148892-91-5)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26-36/37
    4. WGK Germany: 3
    5. RTECS:
    6. F: 10-21
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 148892-91-5(Hazardous Substances Data)

148892-91-5 Usage

Uses

Used in Biochemical Research:
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM is used as a research tool for studying K-RAS interactions with the membrane, for the crystallization of Mycobacterium tuberculosis FtsZ, and as a translation initiation inhibitor for the analysis of the 48S pre-initiation complex.
Used in Cell Signaling and Metabolic Processes:
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM is used as a modulator for G proteins involved in cell signaling, protein synthesis, and other metabolic processes.
Used in Protein Synthesis Studies:
5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM is used as an activator for ADP-ribosylation factors and as a tool to study the initiation of protein translocation across the endoplasmic reticulum, as it plays a role in the GTP binding, hydrolysis, and release cycle required for this process.

Biochem/physiol Actions

Guanosine 5′-[?,γ-imido]triphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 148892-91-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,8,9 and 2 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 148892-91:
(8*1)+(7*4)+(6*8)+(5*8)+(4*9)+(3*2)+(2*9)+(1*1)=185
185 % 10 = 5
So 148892-91-5 is a valid CAS Registry Number.

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