Chiral Helical Lewis Acids for Asymmetric Diels-Alder Catalysts
A new type of chiral helical titanium reagent has been prepared from titanium tetraisopropoxide and a chiral ligand derived from optically pure binaphthol.These reagents have been successfully utilized as an efficient chiral template for the sufficient conformational fixation of α,β-unsaturated aldehydes, thereby allowing efficient enantioface recognition of the substrates for achievement of uniformly high asymmetric induction in asymmetric Diels-Alder reaction with dienes, regardless of reaction temperature.
Maruoka, Keiji,Murase, Noriaki,Yamamoto, Hisashi
p. 2938 - 2939
(2007/10/02)
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