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Benzoic acid, 4-(3,3-dimethoxy-2-methylpropyl)-, ethyl ester (9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

148952-71-0

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  • Benzoic acid, 4-(3,3-dimethoxy-2-methylpropyl)-, ethyl ester (9CI)

    Cas No: 148952-71-0

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148952-71-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 148952-71-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,9,5 and 2 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 148952-71:
(8*1)+(7*4)+(6*8)+(5*9)+(4*5)+(3*2)+(2*7)+(1*1)=170
170 % 10 = 0
So 148952-71-0 is a valid CAS Registry Number.

148952-71-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(3,3-Dimethoxy-2-methyl-propyl)-benzoic acid ethyl ester

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:148952-71-0 SDS

148952-71-0Upstream product

148952-71-0Relevant articles and documents

Antibody catalyzed hydrolysis of enol ethers

Reymond, Jean-Louis,Jahangiri, Guiti K.,Stoudt, Catherine,Lerner, Richard A.

, p. 3909 - 3917 (2007/10/02)

The hydrolysis of alkyl enol ethers to their corresponding carbonyl compounds proceeds by rate determining protonation of the β-carbon to form an activated oxocarbonium ion intermediate and is catalyzed by acids (Kresge, A. J.; Chiang, Y. J. Chem. Soc. B 1967, 53). It can be catalyzed by antibodies with very high enantioselectivity of protonation at the β-carbon to form optically pure carbonyl compounds (Reymond, J.-L.; Janda, K. D.; Lerner, R. A. J. Am. Chem. Soc. 1992, 114, 2257). In the present study, the pH profile of the antibody 14D9 (anti-1) catalyzed, enantioselective hydrolysis of enol ether 4 between pH = 3.1 and pH = 7.2 has been measured in both H2O and D2O at 20°C. The kinetic solvent isotope effect is (kH/kD)cat = 1.75 for the antibody catalyzed reaction and (kH/kD)uncat = 1.92 for the background reaction. The Michaelis-Menten constant Km for substrate 4 changes from 35 μM at low pH to 190 μM. at high pH. Saturation of the catalytic activity is observed at low pH. These observations are consistent with general acid catalysis by an ionizable side chain with pK = 5.2, presumably a carboxyl group, in the active site. A maximum rate acceleration kcat/kuncat = 8200 is obtained at the high pH end of the profile, and a maximum turnover number of 9.75 × 10-5 s-1 is obtained at the low pH end. Enol ethers 15-21 are also catalytically hydrolyzed by 14D9. The maximum turnover numbered measured is 0.39 s-1 with 17 at pH = 6.0 at 20°C. The catalytic effect kcat/kuncat is influenced by the structure of the enol ether. Catalysis increases by a factor of 12 between 15 and its β-methyl analog 4 and by a factor of 34 between the six-membered ring enol ether 19 and its five-membered ring analog 17. These rate effects may reflect the principle of strain in catalysis. They suggest that hydrophobic interactions directly participate in transition-state stabilization, which is unexpected for an acid-base reaction usually discussed in terms of proton relay mechanisms. The implication of these findings for the design and improvement of antibody catalysts is discussed.

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