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CAS

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149035-77-8

3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-2-FMOC-ERYTHRO-SPHINGOSINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 149035-77-8 Structure

  • Basic information

    1. Product Name: 3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-2-FMOC-ERYTHRO-SPHINGOSINE
    2. Synonyms: 3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-2-FMOC-ERYTHRO-SPHINGOSINE;(2S,3R,4E)-2-AMINO-3-(TERTBUTYLDIMETHYLSILYLOXY)-2-FLUORENYLCARBONYLAMINO-4-OCTADECENE-1-OL
    3. CAS NO:149035-77-8
    4. Molecular Formula: C39H61NO4Si
    5. Molecular Weight: 635.99
    6. EINECS: N/A
    7. Product Categories: Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols;Inhibitors;Protein Kinase Inhibitors and Activators
    8. Mol File: 149035-77-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 711.6°C at 760 mmHg
    3. Flash Point: 384.2°C
    4. Appearance: /
    5. Density: 1.012g/cm3
    6. Vapor Pressure: 2.96E-21mmHg at 25°C
    7. Refractive Index: 1.521
    8. Storage Temp.: N/A
    9. Solubility: Acetone, Dichloromethane, Ethyl Acetate, Methanol
    10. PKA: 10.83±0.46(Predicted)
    11. CAS DataBase Reference: 3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-2-FMOC-ERYTHRO-SPHINGOSINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-2-FMOC-ERYTHRO-SPHINGOSINE(149035-77-8)
    13. EPA Substance Registry System: 3-O-(TERT-BUTYLDIMETHYLSILYLOXY)-2-FMOC-ERYTHRO-SPHINGOSINE(149035-77-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 149035-77-8(Hazardous Substances Data)

149035-77-8 Usage

Chemical Properties

Colourless Oil

Check Digit Verification of cas no

The CAS Registry Mumber 149035-77-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,0,3 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 149035-77:
(8*1)+(7*4)+(6*9)+(5*0)+(4*3)+(3*5)+(2*7)+(1*7)=138
138 % 10 = 8
So 149035-77-8 is a valid CAS Registry Number.
InChI:InChI=1/C39H61NO4Si/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-28-37(44-45(5,6)39(2,3)4)36(29-41)40-38(42)43-30-35-33-26-22-20-24-31(33)32-25-21-23-27-34(32)35/h19-28,35-37,41H,7-18,29-30H2,1-6H3,(H,40,42)/b28-19+/t36-,37+/m0/s1

149035-77-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,3R,4E)-3-(tert-butyldimethylsilyloxy)-2-(9-fluorenylmethyloxycarbonylamino)-4-octadecene-1-ol

1.2 Other means of identification

Product number -
Other names 3-O-(tert-Butyldimethylsilyloxy)-2-Fmoc-erythro-sphingosine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:149035-77-8 SDS

149035-77-8Downstream Products

149035-77-8Relevant articles and documents

Efficient Synthesis of Sphingosine-1-phosphate, Ceramide-1-phosphate, Lysosphingomyelin, and Sphingomyelin

Kratzer, Bernd,Schmidt, Richard R.

, p. 957 - 964 (2007/10/02)

Readily available D-erythro-azidosphingosine is transformed into 3-O-silyl-protected derivative 6.Reduction of the azido group afforded 3-O-silyl-protected sphingosine 7 which was either converted into N-Fmoc-protected derivative 8 or via N-acylation into ceramide derivatives 16 and 17, respectively.Treatment of 6, 8, and 16 with bis(2-cyanoethoxy)(diisopropylamino)phosphane as monofunctional phsophitylating agent, subsequent oxidation and then removal of the protective groups furnished azidosphingosine-1-phosphate (11), sphingosine-1-phosphate (2), and ceramide-1-phosphate (4), respectively.Treatment of 8 and 17 with bis(diisopropylamino)(2-cyanoethoxy)phosphane as bifunctional phosphitylating agent and then with choline afforded after oxidation and subsequent deprotection lysosphingomyelin (3) and sphingomyelin (1), respectively in high overall yields.All final products are sterochemically pure and possess D-erythro configuration in the sphingosine moiety. - Key Words: Phosphosphingolipids, synthesis of/ Azidosphingosine/ Azidosphingosine-1-phosphate/ Phosphitylation/ Sphingosine phosphates

An efficient synthesis of sphingosine-1-phosphate

Kratzer, Bernd,Schmidt, Richard R.

, p. 1761 - 1764 (2007/10/02)

The total synthesis of D-erythro-sphingosine-1-phosphate (2) via the phosphoramidite approach, starting from 3-O-TBDMS-protected D-erythro-azidosphingosine 3 is described.

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