The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
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Page/Page column 87
(2016/06/01)
HCV NS3 PROTEASE INHIBITORS
The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
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Page/Page column 67
(2013/06/05)
Conformational analysis of tandospirone in aqueous solution: Lead evolution of potent dopamine D4 receptor ligands
The significant contribution of folded conformation (2) of the anxiolytic tandospirone (1) in aqueous solution was verified by dynamic 1H NMR. A structurally rigid mimic of 2 was designed and synthesized to evaluate the implication of 2 towards neuroleptic receptor binding. The designed structures provided a new rigid scaffold for dopamine D4 ligands.
Quinoline Alkaloids. Part 25. Synthesis of Isopropenylfuroquinolines and a Hydroxyisopropylfuroquinolinone from Copper(I) acetylides
Reactions of 3-halo-4-hydroxy- and 4-methoxy-1-methyl-2-quinolinones with copper(I) isopropenylacetylide gave 2-isopropenyl-5-methyl-4-oxofuroquinoline (4).The isopropenylfuroquinoline (18) with linear annelation was prepared from 3-halo-4-methoxy-2-quinolinones and hydroxyisopropylfuroquinolinone (11) was obtained from copper(I) (2-tetrahydropyranyloxyisopropyl)acetylide.The 13C n.m.r. spectra of 3-halo-4-methoxy-2-quinolinones are discussed.
Gaston, John L.,Greer, Robert J.,Grundon, Michael F.
p. 1877 - 1892
(2007/10/02)
Ylides of Heterocycles, VIII. Reactions of Iodonium-Ylides with Acids
The reaction of various organic and inorganic acids (HX) with iodonium ylides 2 leads to nucleophilic substitution of the iodobenzene substituent by the anion X(-) to yield the heterocycles 5.Some of them are hydrolyzed to the hydroxy compounds 3 or reduced to the starting compounds 1 under the reaction conditions.Reaction of the iodonium ylide 2b with monomethyl sulfate gives the salt 9, which with bases undergoes nucleophilic substitution to compounds 8 and 10-12, respectively, or is converted to 2b again. - Keywords: 3-Acetoxy-4-hydroxy-2-quinolones; 2-Oxoquinoline-4-olates; 3-Substituted 4-hydroxy-2-quinolones
Pongratz, Erik,Kappe, Thomas
p. 231 - 242
(2007/10/02)
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