- Analysis of 13C NMR Substituent Chemical Shifts in Some (Aryl)(2-nitrobenzothiophen-3-yl)amines: a New Class of Compounds with Analgesic, Anti-Exudative and Anti-Inflammatory Activities Showing Low Mutagenicity
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The 13C NMR chemical shift values of (aryl)(2-nitrobenzothiophen-3-yl)amines were measured in DMSO-d6 solutions, suggesting the occurrence of an alternate charge polarization at C-3, C-2, C-3a, C-7a, C-4 and C-5.A dual substituent parameter analysis of the experimental data indicates a large or a low resonance contribution for aryl para and meta substituents, respectively, while the inductive component remains constant throughout. - Keywords: 13C NMR; substituent chemical shifts; anilines; (aryl)(2-nitrobenzothiophen-3-yl)amines; alternate charge polarization
- Lamartina, Liliana,Spinelli, Domenico,Guerrera, Francesco,Sarva, Maria Concetta
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p. 883 - 888
(2007/10/03)
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- Synthesis and pharmacological properties of 2-nitro-3-substituted-amino benzo[b]thiophenes and their 5-chloro derivatives
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This paper reports the synthesis and the pharmacological evaluation of some 2-nitro-3-N-phenylamino-benzo[b]-thiophenes and 5-chloro derivatives of the most active of these compounds; in addition, some 5-chloro derivatives of 2-nitro-3-alkylen- or phenylen-diamino-benzo[b]thiophenes previously synthesized were prepared. These compounds were screened for analgesic, antiexudative and antiinflammatory activities related to phenylbutazone. Nitration of 5-chloro-3-bromobenzo[b]thiophene was also studied.
- Guerrera,Salerno,Sarva,Siracusa,Lamartina,Caruso,Cutuli
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p. 1149 - 1160
(2007/10/02)
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