149498-94-2Relevant articles and documents
An efficient new enzymatic method for the preparation of β-aryl-β-amino acid enantiomers
Tasnadi, Gabor,Forro, Eniko,Fueloep, Ferenc
, p. 2072 - 2077 (2008/12/22)
An efficient synthesis of β-aryl-β-amino acid enantiomers has been developed via the lipase-catalysed enantioselective hydrolysis of the corresponding racemic ethyl esters in an organic solvent. High enantioselectivities (E >100) were observed when the lipase PS-catalysed reactions were performed with H2O (0.5 equiv) in diisopropyl ether at 45 °C. The products could be easily separated and were obtained in good yields of ≥40%.
Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp sequence of fibrinogen. (Aminobenzamidino)succinyl (ABAS) series of orally active fibrinogen receptor antagonists
Zablocki,Rico,Garland,Rogers,Williams,Schretzman,Rao,Bovy,Tjoeng,Lindmark,Toth,Zupec,McMackins,Adams,Miyano,Markos,Milton,Paulson,Herin,et al.
, p. 2378 - 2394 (2007/10/02)
Our initial orally active fibrinogen receptor antagonist benzamidinopentanoyl (BAP) series which was discovered through truncation of our iv antiplatelet agent (SC-52012) demonstrated modest oral activity in canine studies (ethyl [5-(4-amidinophenyl)penta
Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
-
, (2008/06/13)
Novel substituted heterocyclic derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.