Efficient Synthesis of tert-Butyl 2,4-Dialkynylated and 2-Alkynylated-4-Arylated-1H-Imidazole-1-Carboxylate via Regioselective Sonogashira Cross-Coupling Reaction
An efficient regioselective cross-coupling reactions of tert-butyl 2,4-dibrominated-5-methyl-1H-imidazole-1-carboxylate is reported. This new synthetic route runs under simple and mild conditions and selectively gives an easy access to 2,4-dialkynylated a
HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF
Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.
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Page/Page column 86; 87; 108
(2015/07/07)
HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS
Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.
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Page/Page column 72; 93
(2014/01/18)
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