1496637-05-8Relevant articles and documents
Acid-catalyzed in situ generation of less accessible or unprecedented N-Boc imines from N-Boc aminals
Kano, Taichi,Yurino, Taiga,Asakawa, Daisuke,Maruoka, Keiji
supporting information, p. 5532 - 5534 (2013/06/27)
Crafty aminals: The in situ generation of hitherto unattainable alkynyl-substituted N-Boc-protected imines was realized by the acid-catalyzed elimination of tert-butyl carbamate from N-Boc aminals. A wide variety of N-Boc imines can be generated, which ca
Organocatalytic asymmetric synthesis of propargylamines with two adjacent stereocenters: Mannich-type reactions of in situ generated C-alkynyl imines with β-keto esters
Kano, Taichi,Yurino, Taiga,Maruoka, Keiji
supporting information, p. 11509 - 11512 (2013/11/06)
Side by side: The title reaction is catalyzed by the chiral Bronsted acid (S)-1, and affords hitherto less accessible chiral propargylamines, having two adjacent stereocenters, in good to excellent diastereo- and enantioselectivities. Boc=tert-butoxycarbonyl. Copyright