149806-11-1

Basic information

• Product Name: 2-PIPERIDIN-1-YL-PYRIMIDINE-5-CARBALDEHYDE
• Synonyms: ASISCHEM C63450;2-PIPERIDIN-1-YL-PYRIMIDINE-5-CARBALDEHYDE;2-piperidin-1-ylpyrimidine-5-carbaldehyde(SALTDATA: FREE)
• CAS NO: 149806-11-1
• Molecular Formula: C₁₀H₁₃N₃O
• Molecular Weight: 191.23
• Mol File: 149806-11-1.mol

Chemical Properties

• Boiling Point: 374.548°C at 760 mmHg
• Flash Point: 180.32°C
• Appearance: /
• Density: 1.197g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 2-PIPERIDIN-1-YL-PYRIMIDINE-5-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PIPERIDIN-1-YL-PYRIMIDINE-5-CARBALDEHYDE(149806-11-1)
• EPA Substance Registry System: 2-PIPERIDIN-1-YL-PYRIMIDINE-5-CARBALDEHYDE(149806-11-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 149806-11-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-Piperidin-1-yl-pyrimidine-5-carbaldehyde is used as a key intermediate in the synthesis of drug analogs, contributing to the development of new therapeutic agents. Its derivatives are of particular interest due to their potential biological activities, which can be harnessed for medicinal applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-Piperidin-1-yl-pyrimidine-5-carbaldehyde is used as a building block for the creation of novel compounds with potential therapeutic properties. 2-PIPERIDIN-1-YL-PYRIMIDINE-5-CARBALDEHYDE's structure allows for the exploration of various chemical modifications, which can lead to the discovery of new drugs with improved efficacy and safety profiles.
Used in Scientific Research:
2-Piperidin-1-yl-pyrimidine-5-carbaldehyde is employed in specialized research applications, where its unique chemical properties can be investigated for potential uses in various scientific disciplines. 2-PIPERIDIN-1-YL-PYRIMIDINE-5-CARBALDEHYDE's versatility makes it a valuable tool for researchers seeking to understand its role in biological systems and its potential for creating new materials or compounds.

InChI:InChI=1/C10H13N3O/c14-8-9-6-11-10(12-7-9)13-4-2-1-3-5-13/h6-8H,1-5H2

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 57356-64-6 5-bromo-2-(piperidin-1-yl)pyrimidine 

Downstream Products

• 1033619-89-4 (4-fluoro-phenyl)-(2-piperidin-1-yl-pyrimidin-5-ylmethyl)-amine 

Relevant articles and documents

ION CHANNEL MODULATORS

The present teachings provide carboxylic amide compounds that can modulate the activity of ion channels in a mammal. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.

ION CHANNEL MODULATORS

The present teachings provide compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R2, R3, p, and X are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.

ION CHANNEL MODULATORS

The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R1', R2, R3, R4 R4', and p are defined herein. The present teachings also provide processes for producing said compounds and their pharmaceutically acceptable salts, hydrates and esters, and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds including their pharmaceutically acceptable salts, hydrates and esters. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.

CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS

The present teachings provide compounds of Formula (I) wherein Ar, R1, R2, R3, X, p and n are defined herein. The present teachings also provide processes for producing said compounds and methods of treating a pathological condition or disorder, or alleviating a symptom thereof, using said compounds. The compounds can be useful in modulating ion channel activity including treating a variety of conditions associated with the abnormal modulation of one or more voltage-gated calcium channels.