149838-23-3Relevant articles and documents
A method of manufacturing an optical isomer [...]
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Paragraph 0033; 0034, (2017/04/11)
PROBLEM TO BE SOLVED: To asymmetrically synthesize constituent optically active substances of doranidazole and clarify pharmacological and physicochemical features of each of the optically active substances.SOLUTION: A method of producing a compound of st
A method of manufacturing an optical isomer [...]
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Paragraph 0039; 0040, (2017/05/10)
PROBLEM TO BE SOLVED: To provide a method of an asymmetric synthesis for a structural enantiomer of doranidazole, and an intermediate used for the manufacturing method.SOLUTION: There is provided a method of manufacturing 2-nitro imidazole derivative repr
R,R,S,S-2-nitroimidazole derivatives
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, (2008/06/13)
High purity 2-nitroimidazole derivatives having excellent radiosensitivity and high safety and useful as a drug to be used along with radiotherapy of various cancers can be prepared at a high yield from inexpensive diester of tartaric acid according to the following reaction formua, STR1 wherein R1 and R2 may be the same or different and each individually represents an aliphatic group or an aromatic group, and X represents a halogen atom.
2-nitroimidazole derivative, production thereof, and radiosensitizer containing the same as active ingredient
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, (2008/06/13)
The present invention relates to a 2-nitroimidazole derivative represented by the following general formula (I): STR1 wherein R1, R2 and R3 may be the same or different from each other and mean individually a hydrogen atom or an acyl group, and a radiosensitizer containing the same. The compound (I) according to this invention has an excellent radiosensitizing effect and high safety, so that a radiosensitizer containing the same is remarkably useful in the radiotherapy of cancers.
