- Synthesis method of 2-chloropyrimidine-4-formic acid
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The invention relates to a synthesis method of 2-chloropyrimidine-4-formic acid. 2, 4-dichloropyrimidine is used as a starting raw material, the target product 2-chloropyrimidine-4-formic acid is prepared through a two-step reaction, and the whole synthesis process is high in yield, the purity is good, and the operation is convenient, green and environmentally friendly, therefore the method is suitable for industrial production.
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Paragraph 0024; 0029
(2020/07/21)
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- Continuous synthesis method of 2-chloropyrimidine-4-formic acid compound
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The invention provides a continuous synthesis method of a 2-chloropyrimidine-4-formic acid compound. The 2-chloropyrimidine-4-formic acid compound has a structure represented by a formula I, wherein in the formula I, R1 and R2 are respectively and independently selected from hydrogen, alkoxy, aryl, benzyl or fluorine. The synthesis method comprises the following steps: S1, under the action of a non-noble metal catalyst, carrying out continuous methylation reaction on a compound A and a methyl Grignard reagent B to obtain a compound C, wherein the compound A is a compound shown in the specification, the compound C is a compound shown in the specification, R1 and R2 are respectively and independently selected from hydrogen, alkoxy, aryl, benzyl or fluorine, and the non-noble metal catalyst is one or more of ferric salt, cobalt salt and nickel salt; and S2, carrying out continuous oxidation reaction on the compound C under the action of oxygen, an oxidation catalyst and an additive, and thus obtaining the 2-chloropyrimidine-4-formic acid compound. By adopting the process provided by the invention to synthesize the 2-chloropyrimidine-4-formic acid compound, the aspects of cost, yield,environmental friendliness and the like can be considered.
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Paragraph 0045-0046; 0056-0063
(2020/01/25)
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- Method for preparing 2-chloropyrimidine-4 formic acid
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The invention relates to a method for preparing 2-chloropyrimidine-4 formic acid. The method comprises the following steps: performing debydrochlorination reaction on 2-chlorine-4-methyl pyridine hydrochloride and phosphorus oxychloride and separating, thereby acquiring 2-chlorine-4-methyl pyridine; and performing methyl oxidizing reaction on 2-chlorine-4-methyl pyridine and methyl oxidant and separating, thereby acquiring 2-chloropyrimidine-4 formic acid. According to the process route provided by the invention, the yield of the target product is high, the process route can be amplified, the raw materials can be easily acquired and have low cost, and industrial production can be carried out.
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Paragraph 0016; 0019; 0020; 0021; 0022; 0024; 0025
(2017/01/02)
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- Products of a microbiological process for the production of 2-halo-pyrimidine-4-carboxylic acids
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A 2-halo-pyrimidine-4-carboxylic acid of formula: STR1 wherein X is a halogen atom, for example, 2-chloro-pyrimidine-4-carboxylic acid. A 2-substituted-pyrimidine-4-carboxylic acid derivative of formula: STR2 wherein R1 is a halogen atom, NH2 --, HO-- or a C1 -C4 alkoxy group and R2 is a C1 -C4 alkoxy group or a halogen atom with the proviso that, if R1 is a HO-- group, R2 is not a halogen atom and with the proviso that, if R2 is a halo group, R1 is not an amino group. A 2-substituted-pyrimidine-4-carboxylic acid derivative of formula III wherein R1 is a HO-- group and R2 is an ethoxy group.
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