149965-78-6

Basic information

• Product Name: 4-PROP-2-YN-1-YLMORPHOLINE
• Synonyms: 4-PROP-2-YN-1-YLMORPHOLINE;4-(2-propyn-1-yl)-Morpholine;Benzyl but-3-ynylcarbamate;benzyl but-3-yn-1-ylcarbaMate;But-3-ynyl-carbamic acid benzyl ester
• CAS NO: 149965-78-6
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 125.0
• Mol File: 149965-78-6.mol

Chemical Properties

• Boiling Point: 168.1 °C at 760 mmHg
• Flash Point: 45.8 °C
• Appearance: /
• Density: 0.99 g/cm³
• Storage Temp.: 2-8°C
• PKA: 11.90±0.46(Predicted)
• CAS DataBase Reference: 4-PROP-2-YN-1-YLMORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PROP-2-YN-1-YLMORPHOLINE(149965-78-6)
• EPA Substance Registry System: 4-PROP-2-YN-1-YLMORPHOLINE(149965-78-6)

Safety Data

• Hazardous Substances Data: 149965-78-6(Hazardous Substances Data)

Usage

Uses

Used in Agrochemical Synthesis:
4-Prop-2-yn-1-ylmorpholine is used as an intermediate in the synthesis of agrochemicals for its potential role in the development of new pesticides or herbicides. The morpholine structure in 4-Prop-2-yn-1-ylmorpholine may contribute to the effectiveness of these products in agricultural applications.
Used in Pharmaceutical Industry:
4-Prop-2-yn-1-ylmorpholine is used as a building block in the pharmaceutical industry for the synthesis of various drug molecules. The morpholine ring's unique properties may allow for the creation of new medications with improved efficacy or reduced side effects.
Used in Rubber Production:
4-Prop-2-yn-1-ylmorpholine is used as an additive in the rubber production process to enhance the properties of rubber materials. The morpholine structure may improve the flexibility, durability, or other characteristics of rubber products.
Used in Corrosion Control:
4-Prop-2-yn-1-ylmorpholine is used as a corrosion inhibitor in steam and water systems to protect against the damaging effects of corrosion. The presence of the morpholine ring may provide a protective layer or chemical interaction that reduces corrosion rates in these systems.

Upstream product

• 136918-14-4 phthalimide 
• 88211-50-1 4-amino-1-butyne hydrochloride 
• 501-53-1 benzyl chloroformate 
• 6089-09-4 4-pentynoic acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 876131-18-9 [4-(4-Iodophenyl)but-3-ynyl]carbamic acid benzyl ester 
• 1158803-92-9 benzyl 4-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)but-3-ynylcarbamate 
• 1184951-86-7 benzyl 4-[6-(tert-butyldimethylsilyloxy)naphthalen-2-yl]but-3-ynylcarbamate 
• 1191953-06-6 benzyl but-3-ynyl(methoxymethyl)carbamate 
• 960398-79-2 C₅₆H₆₂N₂O₁₀ 
• 960398-44-1 (4-(4-(4-(bis-(2-(4-benzyloxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethyl)amino)butyl)phenyl)butyl)carbamic acid benzyl ester 
• 960398-77-0 C₄₅H₅₃N₃O₆S 
• 960398-28-1 (4-(4-(4-(2-(3-(benzylmethanesulfonylamino)-4-benzyloxyphenyl)-2(R)-hydroxyethylamino)butyl)phenyl)butyl)carbamic acid benzyl ester 
• 960398-78-1 (4-(4-(4-(bis-(2-(3-(benzylmethanesulfonylamino)-4-benzyloxyphenyl)-2(R)-hydroxyethyl)amino)butyl)phenyl)butyl)carbamic acid benzyl ester 
• 960398-41-8 2-benzyloxy-5-(2-(4-(4-(4-benzyloxycarbonylaminobutyl)phenyl)butylamino)-1-(R)-hydroxyethyl)benzoic acid methyl ester 
• 960398-42-9 (4-(4-(4-(2-(4-benzyloxy-3-hydroxymethylphenyl)-2-(R)-hydroxyethylamino)butyl)phenyl)butyl)carbamic acid benzyl ester 
• 1173165-40-6 C₃₈H₄₅N₃O₅ 
• 960398-10-1 (4-(4-(4-(2-(4-benzyloxy-3-formylaminophenyl)-2(R)-hydroxyethylamino)butyl)phenyl)butyl)carbamic acid benzyl ester 
• 960398-39-4 (4-(4-(4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyl)phenyl)butyl)carbamic acid benzyl ester 

Relevant articles and documents

An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase

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Formal alkyne aza-prins cyclization: Gold(I)-catalyzed cycloisomerization of mixed N,O-acetals generated from homopropargylic amines to highly substituted piperidines

(Chemical Equation Presented). A new gold(I)-catalyzed cycloisomerization to access highly substituted piperidines has been developed. By combining a conceptually new way of generating iminium ions using cationic gold(I) complexes and an efficient cyclization reaction that can minimize a potentially competing aza-Cope rearrangement, the proposed reaction successfully circumvents a long-standing problem in the classical aza-Prins reaction. Synthetic utility of the catalytic reaction was demonstrated by a synthesis of optically active 2-alkyl-piperidin-4-one.

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