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4-Prop-2-yn-1-ylmorpholine is a chemical compound that belongs to the class of organic compounds known as morpholines. Morpholines are characterized by a six-membered saturated ring structure that includes one nitrogen atom, one oxygen atom, and four carbon atoms. This specific compound is not extensively discussed or researched in scientific literature, indicating that it may not be a common or widely used substance across various industries or fields of research.

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  • 149965-78-6 Structure
  • Basic information

    1. Product Name: 4-PROP-2-YN-1-YLMORPHOLINE
    2. Synonyms: 4-PROP-2-YN-1-YLMORPHOLINE;4-(2-propyn-1-yl)-Morpholine;Benzyl but-3-ynylcarbamate;benzyl but-3-yn-1-ylcarbaMate;But-3-ynyl-carbamic acid benzyl ester
    3. CAS NO:149965-78-6
    4. Molecular Formula: C12H13NO2
    5. Molecular Weight: 125.0
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 149965-78-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 168.1 °C at 760 mmHg
    3. Flash Point: 45.8 °C
    4. Appearance: /
    5. Density: 0.99 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 11.90±0.46(Predicted)
    10. CAS DataBase Reference: 4-PROP-2-YN-1-YLMORPHOLINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-PROP-2-YN-1-YLMORPHOLINE(149965-78-6)
    12. EPA Substance Registry System: 4-PROP-2-YN-1-YLMORPHOLINE(149965-78-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 149965-78-6(Hazardous Substances Data)

149965-78-6 Usage

Uses

Used in Agrochemical Synthesis:
4-Prop-2-yn-1-ylmorpholine is used as an intermediate in the synthesis of agrochemicals for its potential role in the development of new pesticides or herbicides. The morpholine structure in 4-Prop-2-yn-1-ylmorpholine may contribute to the effectiveness of these products in agricultural applications.
Used in Pharmaceutical Industry:
4-Prop-2-yn-1-ylmorpholine is used as a building block in the pharmaceutical industry for the synthesis of various drug molecules. The morpholine ring's unique properties may allow for the creation of new medications with improved efficacy or reduced side effects.
Used in Rubber Production:
4-Prop-2-yn-1-ylmorpholine is used as an additive in the rubber production process to enhance the properties of rubber materials. The morpholine structure may improve the flexibility, durability, or other characteristics of rubber products.
Used in Corrosion Control:
4-Prop-2-yn-1-ylmorpholine is used as a corrosion inhibitor in steam and water systems to protect against the damaging effects of corrosion. The presence of the morpholine ring may provide a protective layer or chemical interaction that reduces corrosion rates in these systems.

Check Digit Verification of cas no

The CAS Registry Mumber 149965-78-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,9,6 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 149965-78:
(8*1)+(7*4)+(6*9)+(5*9)+(4*6)+(3*5)+(2*7)+(1*8)=196
196 % 10 = 6
So 149965-78-6 is a valid CAS Registry Number.

149965-78-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(Prop-2-yn-1-yl)morpholine,4-(2-propyn-1-yl)-Morpholine

1.2 Other means of identification

Product number -
Other names benzyl 3-butynylcarbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:149965-78-6 SDS

149965-78-6Relevant articles and documents

An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase

Al-Khawaldeh, Islam,Al Yasiri, Mohammed J.,Aldred, Gregory G.,Basmadjian, Christine,Bordoni, Cinzia,Harnor, Suzannah J.,Heptinstall, Amy B.,Hobson, Stephen J.,Jennings, Claire E.,Khalifa, Shaimaa,Lebraud, Honorine,Martin, Mathew P.,Miller, Duncan C.,Shrives, Harry J.,de Souza, Jo?o V.,Stewart, Hannah L.,Temple, Max,Thomas, Huw D.,Totobenazara, Jane,Tucker, Julie A.,Tudhope, Susan J.,Wang, Lan Z.,Bronowska, Agnieszka K.,Cano, Céline,Endicott, Jane A.,Golding, Bernard T.,Hardcastle, Ian R.,Hickson, Ian,Wedge, Stephen R.,Willmore, Elaine,Noble, Martin E. M.,Waring, Michael J.

, p. 10001 - 10018 (2021/07/26)

NF-κB-inducing kinase (NIK) is a key enzyme in the noncanonical NF-κB pathway, of interest in the treatment of a variety of diseases including cancer. Validation of NIK as a drug target requires potent and selective inhibitors. The protein contains a cysteine residue at position 444 in the back pocket of the active site, unique within the kinome. Analysis of existing inhibitor scaffolds and early structure-activity relationships (SARs) led to the design of C444-targeting covalent inhibitors based on alkynyl heterocycle warheads. Mass spectrometry provided proof of the covalent mechanism, and the SAR was rationalized by computational modeling. Profiling of more potent analogues in tumor cell lines with constitutively activated NIK signaling induced a weak antiproliferative effect, suggesting that kinase inhibition may have limited impact on cancer cell growth. This study shows that alkynyl heterocycles are potential cysteine traps, which may be employed where common Michael acceptors, such as acrylamides, are not tolerated.

Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH

Li, Xue-Meng,Lv, Wei,Guo, Si-Yang,Li, Ya-Xin,Fan, Bing-Zhi,Cushman, Mark,Kong, Fan-Sheng,Zhang, Jun,Liang, Jian-Hua

supporting information, p. 235 - 254 (2019/03/27)

In general, potent non-ketolide versions of erythromycin possessed conformationally constricted two- or three-atom-length sidechains at 3-OH. Novel 14-membered non-ketolides possessing long spacers beyond three-atom length were evaluated for antibacterial

Formal alkyne aza-prins cyclization: Gold(I)-catalyzed cycloisomerization of mixed N,O-acetals generated from homopropargylic amines to highly substituted piperidines

Cheoljae, Kim,Hyo, Jin Bae,Ji, Hyung Lee,Wook, Jeong,Haejin, Kim,Sampath, Vasu,Young, Ho Rhee

supporting information; scheme or table, p. 14660 - 14661 (2010/02/28)

(Chemical Equation Presented). A new gold(I)-catalyzed cycloisomerization to access highly substituted piperidines has been developed. By combining a conceptually new way of generating iminium ions using cationic gold(I) complexes and an efficient cyclization reaction that can minimize a potentially competing aza-Cope rearrangement, the proposed reaction successfully circumvents a long-standing problem in the classical aza-Prins reaction. Synthetic utility of the catalytic reaction was demonstrated by a synthesis of optically active 2-alkyl-piperidin-4-one.

Prodrugs activated by targeted catalytic proteins

-

, (2008/06/13)

Prodrugs that are activated by and conjugated to a catalytic antibody conjugated to a moiety that binds to a tumor cell population are provided.

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