Effect of Trifluoromethyl and Other Substituents on Activity of Xanthines at Adenosine Receptors
An aryl p-(trifluoromethyl) substituent increases the affinity of 1,3-disubstituted 8-phenylxanthines at A2a-adenosine receptors, while having little effect on affinity at A1-adenosine receptors.In contrast, an aryl p-(trifluoromethy
