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METHYL 5-PENTAFLUOROETHYL-2-PROPYLIMIDAZOLE-4-CARBOXYLATE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 150097-92-0 Structure
  • Basic information

    1. Product Name: METHYL 5-PENTAFLUOROETHYL-2-PROPYLIMIDAZOLE-4-CARBOXYLATE
    2. Synonyms: METHYL 5-PENTAFLUOROETHYL-2-PROPYLIMIDAZOLE-4-CARBOXYLATE
    3. CAS NO:150097-92-0
    4. Molecular Formula: C10H11F5N2O2
    5. Molecular Weight: 286.2
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 150097-92-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 354.5±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.368±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 8.38±0.10(Predicted)
    10. CAS DataBase Reference: METHYL 5-PENTAFLUOROETHYL-2-PROPYLIMIDAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: METHYL 5-PENTAFLUOROETHYL-2-PROPYLIMIDAZOLE-4-CARBOXYLATE(150097-92-0)
    12. EPA Substance Registry System: METHYL 5-PENTAFLUOROETHYL-2-PROPYLIMIDAZOLE-4-CARBOXYLATE(150097-92-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 150097-92-0(Hazardous Substances Data)

150097-92-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 150097-92-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,0,9 and 7 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 150097-92:
(8*1)+(7*5)+(6*0)+(5*0)+(4*9)+(3*7)+(2*9)+(1*2)=120
120 % 10 = 0
So 150097-92-0 is a valid CAS Registry Number.

150097-92-0Relevant articles and documents

Efficient Synthesis of Fluoroalkylated Imidazoles via a Metal-Free Cascade Michael Addition/Azidation/Cycloamination Process

Wu, Jun,Zhang, Hui,Ding, Xiao,Tan, Xuefei,Shen, Hong C.,Chen, Jie,He, Weimin,Deng, Hongmei,Song, Liping,Cao, Weiguo

, p. 6758 - 6763 (2018/11/30)

In the presence of KI and (diacetoxyiodo)benzene (PIDA), primary amines bearing an α-hydrogen can be efficiently converted to fluoroalkylated imidazoles by reacting with fluoroalkylated alkynes and sodium azide via a cascade Michael addition/azidation/cycloamination process. KI plays a crucial role in this reaction by generating iodine(I) species to promote the cyclization. Substrate scope was explored, and the application of this protocol was demonstrated. Additionally, a plausible reaction mechanism was proposed.

Practical Synthesis and Regioselective Alkylation of Methyl 4(5)-(Pentafluoroethyl)-2-propylimidazole-5(4)-carboxylate To Give DuP 532, a Potent Angiotensin II Antagonist

Pierce, Michael E.,Carini, David J.,Huhn, George F.,Wells, Gregory J.,Arnett, John F.

, p. 4642 - 4645 (2007/10/02)

DuP 532 (2), which is a potent angiotensin II receptor antagonist, has been prepared by two different routes.One route, which is more practical for large-scale synthesis, required the preparation of methyl 4(5)-(pentafluoroethyl)-2-propylimidazole-5(4)-carboxylate (9).This imidazole was synthesized in five steps from commercially available 11 in 32percent overall yield.Alternate perfluoroalkylation methods of the iodoimidazole precursor 14 are presented.Imidazole 9 is remarkably stable to basic conditions and is alkylated by 2--4'-(bromomethyl) -1,1'-biphenyl (8), giving only the desired regioisomer.A comparison of the alkylation of the trisubstituted precursors and analogues to 9 with 8 indicate that even under mildly basic conditions (K2CO3/DMF), the mechanism is SE2cB (anionic), except for 2-propyl-4(5)-(hydroxymethyl)imidazole (11) which alkylates as a neutral species (SE2')

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