150108-66-0Relevant articles and documents
Synthesis of thienopyridinones via hydrazide-alkyne cyclization
Balci, Metin,Cokol, Nalan Korkmaz,Dengiz, Cagatay,Erden, Kübra,Gunay, Furkan Melih
, (2020/04/08)
A novel and efficient method for the synthesis of thieno[3,2-c]pyridinones have been developed. The synthetic strategy relies on the synthesis of halothiophene esters utilized as substrates for subsequent Sonogashira cross-coupling reactions. Hydrazinolysis of corresponding esters and following hydrazide-alkyne ring closure transformations resulted in target thienopyridinones in good yields. It is also shown that pure hydrazine monohydrate is required to facilitate the hydrazide formations.
SULFONYLUREA DERIVATIVES AND USES THEREOF
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, (2020/12/30)
The present disclosure relates to compounds of Formula (I) and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.
COMPOUNDS FOR TREATING VIRAL INFECTIONS
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Page/Page column 76; 78, (2015/11/09)
The present invention relates to small molecule compounds and their use in the treatment of diseases, in particular viral diseases, in particular hepatitis C virus (HCV).
Design and synthesis of condensed thienocoumarins by Suzuki-Miyaura reaction/lactonization tandem protocol
Iaroshenko, Viktor O.,Ali, Sajid,Mkrtchyan, Satenik,Gevorgyan, Ashot,Babar, Tariq Mahmood,Semeniuchenko, Volodymyr,Hassan, Zahid,Villinger, Alexander,Langer, Peter
supporting information, p. 7135 - 7139 (2013/01/15)
A concise and efficient approach to a series of chromen-4-ones with fused thiophene ring has been developed using the Suzuki-Miyaura reaction of bromothiophene-2- and 3-carboxylates with 2-methoxyboronic acids and subsequent cyclization of prepared alkyl (2-methoxy)aryl thiophene-2- and 3-carboxylates under the action of BBr3/KOtBu. Starting bromothiophenes are easily obtained from corresponding commercially available aminothiophenes by diazotization/bromination reaction.