Metallation in connection with cross-coupling reactions. Coupling of hindered aryls for the synthesis of 4-phenylpyridines as part of Streptonigrin and Lavendamycin analogues
The synthesis of the C-D ring system of Streptonigrin and Lavendamycln alkaloid analogues by cross-coupling under Suzuki's conditions has been studied. Steric hindrance is the main problem. It has been solved either by using strong bases or working in a sealed tube under pressure.
A New Approach to the Synthesis Of Lavendamycin Analogues.
A three-steps approach to the lavendamycin skeleton from benzene, pyridine and quinoline blocks is described.It is based on a new synthetic methodology for the preparation of α-substituted β-carbolines which involves such reactions as Directed Ortho Metal
Rocca, Patrick,Marsais, Fracis,Godard, Alain,Queguiner, Guy
p. 2937 - 2940
(2007/10/02)
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