1501330-86-4

Basic information

• Product Name: 1-Cyclopropylpiperidine-2,4-dione
• Synonyms: 1-Cyclopropylpiperidine-2,4-dione;1-Cyclopropyl-2,4-piperidinedione
• CAS NO: 1501330-86-4
• Molecular Formula: C8H11NO2
• Molecular Weight: 153.17844
• Mol File: 1501330-86-4.mol

Chemical Properties

• Boiling Point: 289.8±23.0 °C(Predicted)
• Appearance: /
• Density: 1.304±0.06 g/cm3(Predicted)
• PKA: 11.96±0.20(Predicted)
• CAS DataBase Reference: 1-Cyclopropylpiperidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopropylpiperidine-2,4-dione(1501330-86-4)
• EPA Substance Registry System: 1-Cyclopropylpiperidine-2,4-dione(1501330-86-4)

Safety Data

• Hazardous Substances Data: 1501330-86-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
1-Cyclopropylpiperidine-2,4-dione is utilized as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to interact with specific biological targets, making it a valuable asset in the design of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
As a compound of interest, 1-Cyclopropylpiperidine-2,4-dione is employed in medicinal chemistry research to explore its interactions with biological systems. Understanding its binding affinity, selectivity, and mechanism of action can lead to the discovery of new drug candidates with improved efficacy and safety profiles.
Used in Drug Synthesis and Characterization:
The synthesis and detailed characterization of 1-Cyclopropylpiperidine-2,4-dione are crucial for elucidating its chemical and pharmacological properties. This knowledge is essential for optimizing its use in drug development and for predicting its behavior in biological systems.

Upstream product

• 76731-85-6 β-cyclopropylaminopropionic acid ethyl ester 
• 1453423-54-5 N-cyclopropyl-N-(2-ethoxycarbonylethyl)malonamic acid ethyl ester 
• 1453423-57-8 1-cyclopropyl-2,4-dioxopiperidine-3-carboxylic acid ethyl ester 

Downstream Products

• 1312414-64-4 5-cyclopropyl-2-phenoxymethyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 

Relevant articles and documents

3-AMINO-2-[2-(ACYLAMINO)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE AS CSNK1 INHIBITORS

Compounds of formula (I), processes for their production and their use as pharmaceuticals. The compounds are inhibitors of Casein kinase 1 alpha and/or delta ( CSNK1α and/or 6) useful for the treatment of proliferative disorders. (l)

Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor

Starting from a singleton chromanone high throughput screening (HTS) hit, we describe a focused medicinal chemistry optimization effort leading to the identification of a novel series of phenoxymethyl-dihydrothiazolopyridone derivatives as selective positive allosteric modulators (PAMs) of the metabotropic glutamate 5 (mGlu5) receptor. These dihydrothiazolopyridones potentiate receptor responses in recombinant systems. In vitro and in vivo drug metabolism and pharmacokinetic (DMPK) evaluation allowed us to select compound 16a for its assessment in a preclinical animal screen of possible antipsychotic activity. 16a was able to reverse amphetamine-induced hyperlocomotion in rats in a dose-dependent manner without showing any significant motor impairment or overt neurological side effects at comparable doses. Evolution of our medicinal chemistry program, structure activity, and properties relationships (SAR and SPR) analysis as well as a detailed profile for optimized mGlu5 receptor PAM 16a are described.