Phase transfer catalyzed reductive acylation of nitrogen-containing heteroaromatics with acetylcobalt tetracarbonyl
Phase transfer catalyzed reductive ring-cleavage acylation of isoxazoles or isothiazoles with acetylcobalt tetracarbonyl gives N-acylated 1-amino-2-alkene-3-ones or thiones.Under the same conditions phthalazine, quinoline and isoquinoline react with acetylcobalt tetracarbonyl to give N-acylated dimers.The reactivity of several other nitrogen-containing heterocycles was also investigated.