150432-37-4

Basic information

• Product Name: 2-(1-carboxy-2-hydroxypropyl)-4-{[5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid
• CAS NO: 150432-37-4
• Molecular Formula: C₁₇H₂₇N₃O₆S
• Molecular Weight: 401.4778
• Mol File: 150432-37-4.mol

Chemical Properties

• Boiling Point: 678°C at 760 mmHg
• Flash Point: 363.8°C
• Density: 1.52g/cm³
• Vapor Pressure: 2.71E-21mmHg at 25°C
• Refractive Index: 1.664
• CAS DataBase Reference: 2-(1-carboxy-2-hydroxypropyl)-4-{[5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-carboxy-2-hydroxypropyl)-4-{[5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid(150432-37-4)
• EPA Substance Registry System: 2-(1-carboxy-2-hydroxypropyl)-4-{[5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid(150432-37-4)

Safety Data

• Hazardous Substances Data: 150432-37-4(Hazardous Substances Data)

Upstream product

• 96036-03-2 meropenem 

Relevant articles and documents

On the reactions of the carbapenem, meropenem, in the soluble fraction of the rat kidney

When meropenem (I) is incubated with the soluble fraction of rat kidney or its ultrafiltrate the carbapenem disappears at a rate of 50 nmol/min per g of kidney at pH 8.4 and 37°C. In both cases the kinetics are inconsistent with the reaction being enzymic and the product has been shown to be a thiol. The same reaction occurs in similar preparations from the kidney of several other mammalian species. The reaction of meropenem with thiols has been investigated: only those having a vicinal amino group react rapidly. The product of the reaction with cysteine has been characterized as the amide (III) of the latter with meropenoic acid (II), the carboxylic acid formed by the hydrolysis of the β-lactam ring of meropenem. It is postulated that the destruction of meropenem in the soluble fraction of rat kidney occurs by the non-enzymic reaction of the carbapenem with endogenous cysteine or related thiols. There is no evidence that this reaction can occur in vivo but it should be considered in the future design of carbapenems.