COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA
The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.
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Page/Page column 80; 85
(2014/10/15)
Evaluation of aminohydantoins as a novel class of antimalarial agents
Given the threat of drug resistance, there is an acute need for new classes of antimalarial agents that act via a unique mechanism of action relative to currently used drugs. We have identified a set of druglike compounds within the Tres Cantos Anti-Malar
Meyers, Marvin J.,Tortorella, Micky D.,Xu, Jing,Qin, Limei,He, Zhengxiang,Lang, Xingfen,Zeng, Wentian,Xu, Wanwan,Qin, Li,Prinsen, Michael J.,Sverdrup, Francis M.,Eickhoff, Christopher S.,Griggs, David W.,Oliva, Jonathan,Ruminski, Peter G.,Jacobsen, E. Jon,Campbell, Mary A.,Wood, David C.,Goldberg, Daniel E.,Liu, Xiaorong,Lu, Yongzhi,Lu, Xin,Tu, Zhengchao,Lu, Xiaoyun,Ding, Ke,Chen, Xiaoping
p. 89 - 93
(2014/02/14)
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