- Synthesis of glucuronic acid derivatives via the efficient and selective removal of a C6 methyl group
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This investigation is related to the development of a general strategy for the synthesis of certain glucuronic acid derivatives. In particular, we report exceptionally selective conditions for removing the C6 methyl protecting group by potassium hydroxide
- Hou, Zhuang,Liu, Yang,Zhang, Xin-xin,Chang, Xiao-wei,Cheng, Mao-sheng,Guo, Chun
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- Preparation method and medical application of sulfanilamide compound with coumarin and glycosyl structure
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The invention belongs to the technical field of medicines, and relates to a sulfanilamide compound with coumarin and glycosyl structures as well as a preparation method and application thereof. The sulfanilamide compound is shown as the general formula I, and the definition of substituent groups in the general formula (1) is shown in the specification. The compound provided by the invention has the effects of inhibiting the activity of carbonic anhydrase IX, further inhibiting the growth of tumor cells and anti-tumor metastasis and invasion. The compound structurally has three active fragments, namely sulfanilamide, glucuronic acid and coumarin, and can form various acting forces such as coordinate bonds, hydrogen bonds and Van der Waals force with Zn in the carbonic anhydrase IX, a hydrophilic region and a hydrophobic region, so that the catalytic activity of the enzyme is inhibited, the effects of anti-tumor growth and metastasis invasion are exerted, and has potential application in the aspect of antitumor drugs.
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Paragraph 0030; 0032-0033; 0036
(2021/06/21)
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- Quinoline compound containing sulfonamide structure as well as preparation method and medical application thereof
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The invention belongs to the technical field of medicines, and relates to a quinoline compound containing a sulfonamide structure as well as a preparation method and medical application of the quinoline compound. The quinoline compound containing the sulf
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Paragraph 0033; 0040-0041
(2021/07/01)
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- Chemical synthesis method of glycyrrtinic acid 3-O-mono-beta-D-glucuronide (GAMG)
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The invention discloses a chemical synthesis method of glycyrrtinic acid 3-O-mono-beta-D-glucuronide (GAMG), and belongs to the fields of organic synthesis, medicinal chemistry, and food science. Abundant and cheap glycyrrhetinic acid is taken as the primary raw material, and GAMG is simply and easily synthesized by following five steps: carboxyl to benzyl ester conversion, glycosidation between C3 hydroxyl groups and a fully benzoylated methyl glucuronate glycosyl donor, methyl removal, benzoyl removal, and benzyl removal. The raw materials and reagents are cheap, the reaction conditions aremild, the operation is simple, the yield is good, and the GAMG chemical synthesis method is feasible.
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Paragraph 0012; 0037-0040
(2019/01/08)
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- Preparation method and medical application of sulfonamide compounds with glucuronic acid structures
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The invention belongs to the technical field of pharmacy, and provides sulfonamide compounds with glucuronic acid structures. Structures of the sulfonamide compounds with the glucuronic acid structures are shown in a general formula (I) and a general form
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Paragraph 0025
(2018/05/30)
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- 2-Deoxy-2-trichloroacetamido-D-glucopyranose derivatives in oligosaccharide synthesis: from hyalouronic acid to chondroitin 4-sulfate trisaccharides
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Suitably protected derivatives of phenyl 2-deoxy-1-thio-2-trichloroacetamido-β-D-glucopyranoside, 6, 15 and 16, a new class of glycosyl donors, were tested in the reaction with sugar acceptors of low reactivity (i.e., the methyl uronate 2).This methodolog
- Coutant, Caroline,Jacquinet, Jean-Claude
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p. 1573 - 1582
(2007/10/02)
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