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3-Isopropylpiperidin-4-one, commonly referred to as IPPI, is a chemical compound with the molecular formula C10H19NO. It is a derivative of piperidinone and is classified within the alpha-amino ketones, a subset of organic compounds. As a colorless liquid with a distinct odor, IPPI is a versatile building block in organic chemistry and is widely recognized for its role as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is also a key starting material in the production of various drugs, notably the synthetic opioid fentanyl. Due to its potential health hazards, it is crucial to handle IPPI with care.

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  • 150668-81-8 Structure
  • Basic information

    1. Product Name: 3-isopropylpiperidin-4-one
    2. Synonyms: 3-isopropylpiperidin-4-one;4-Piperidinone, 3-(1-methylethyl)-;3-ISOPROPYLPIPERIDIN-4-ONE HCL;3-Isopropyl-4-piperidone
    3. CAS NO:150668-81-8
    4. Molecular Formula: C8H15NO
    5. Molecular Weight: 141
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 150668-81-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 214.5±15.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 0.934±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 8.91±0.40(Predicted)
    10. CAS DataBase Reference: 3-isopropylpiperidin-4-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-isopropylpiperidin-4-one(150668-81-8)
    12. EPA Substance Registry System: 3-isopropylpiperidin-4-one(150668-81-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 150668-81-8(Hazardous Substances Data)

150668-81-8 Usage

Uses

Used in Pharmaceutical Synthesis:
3-Isopropylpiperidin-4-one is used as an intermediate in the synthesis of pharmaceuticals for its ability to facilitate the creation of a wide range of drug molecules. Its chemical properties make it a valuable component in the development of new medications.
Used in Organic Chemistry:
In the field of organic chemistry, 3-Isopropylpiperidin-4-one is used as a versatile building block, contributing to the formation of complex organic compounds through various chemical reactions.
Used in the Production of Synthetic Opioids:
3-Isopropylpiperidin-4-one is used as a key starting material in the production of synthetic opioids, such as fentanyl, highlighting its importance in the pharmaceutical industry for the development of potent pain-relief medications.

Check Digit Verification of cas no

The CAS Registry Mumber 150668-81-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,6,6 and 8 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 150668-81:
(8*1)+(7*5)+(6*0)+(5*6)+(4*6)+(3*8)+(2*8)+(1*1)=138
138 % 10 = 8
So 150668-81-8 is a valid CAS Registry Number.

150668-81-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-propan-2-ylpiperidin-4-one

1.2 Other means of identification

Product number -
Other names 3-isopropylpiperidin-4-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:150668-81-8 SDS

150668-81-8Upstream product

150668-81-8Downstream Products

150668-81-8Relevant articles and documents

Debenzylation using catalytic hydrogenolysis in trifluoroethanol, and the total synthesis of (-)-raumacline

Bailey, Patrick D.,Beard, Mark A.,Dang, Hoa P.T.,Phillips, Theresa R.,Price, Richard A.,Whittaker, James H.

, p. 2150 - 2153 (2008/09/20)

N-Debenzylations using catalytic hydrogenolysis often fail to take place unless alcoholic solvents are used, but this can lead to N-alkylation as a side reaction; using trifluoroethanol as the solvent overcomes this problem, and leads to highly reliable hydrogenolyses for a wide range of substrates, including the final deprotection step in our total synthesis of (-)-raumacline.

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