150712-24-6

Basic information

• Product Name: 5-BENZYL-1H-PYRAZOL-3-AMINE
• Synonyms: 5-BENZYL-1H-PYRAZOL-3-AMINE;5-Benzyl-2H-pyrazol-3-amine
• CAS NO: 150712-24-6
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.218
• Mol File: 150712-24-6.mol

Chemical Properties

• Boiling Point: 405.316 °C at 760 mmHg
• Flash Point: 227.89 °C
• Appearance: /
• Density: 1.214 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.655
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.92±0.10(Predicted)
• CAS DataBase Reference: 5-BENZYL-1H-PYRAZOL-3-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BENZYL-1H-PYRAZOL-3-AMINE(150712-24-6)
• EPA Substance Registry System: 5-BENZYL-1H-PYRAZOL-3-AMINE(150712-24-6)

Safety Data

• Hazardous Substances Data: 150712-24-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
5-Benzyl-1H-pyrazol-3-amine is utilized as a key intermediate in the development of novel antifungal, antimicrobial, and anti-inflammatory drugs. Its unique structure allows for the exploration of new therapeutic agents that can combat various infections and inflammations.
Used in Organic Synthesis:
In the field of organic chemistry, 5-Benzyl-1H-pyrazol-3-amine serves as a versatile building block for the synthesis of a variety of heterocyclic compounds. Its presence in these compounds can influence their chemical reactivity and potential applications in different chemical processes.
Used in Medicinal Chemistry:
5-Benzyl-1H-pyrazol-3-amine is employed as a scaffold in medicinal chemistry for the design and synthesis of new pharmaceuticals. Its potential biological activities make it a promising candidate for further research and development into effective treatments for various diseases and conditions.

InChI:InChI=1/C10H11N3/c11-10-7-9(12-13-10)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,11,12,13)

Upstream product

• 19212-27-2 3-oxo-4-phenylbutyronitrile 
• 101-97-3 Ethyl 2-phenylethanoate 
• 33472-02-5 2-oxo-3-phenylpropanenitrile 

Downstream Products

• 852443-62-0 (5-benzyl-2H-pyrazol-3-yl)-(2,5-dichloropyrimidin-4-yl)amine 

Relevant articles and documents

5- OR 7-AZAINDAZOLES AS BETA-LACTAMASE INHIBITORS

The present invention relates to β-lactamase inhibitors having the following general formula (I): wherein R1-R4 and X1-X2 are defined in the specification, pharmaceutical composition thereof, and use thereof for the treatment of a bacterial infection, alone or in combination with β-lactam antibiotics and/or other antibiotics and/or other β-lactamase inhibitors.

PYRROLOTRIAZINE KINASE INHIBITORS

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity of such as Jak2 and CK2, thereby making them useful as antiproliferative agents for the treat

HETEROCYCLIC COMPOUNDS AS INHIBITORS OF CXCR2

The present invention relates to compounds of formula (I) wherein R1, R2, X, Y and Z are as defined in the specification.

5-SULFANYLMETHYL-PYRAZOLO [1,5-A] PYRIMIDIN-7-OL DERIVATIVES AS CXCR2 ANTAGONISTS

The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.

PYRROLOTRIAZINE KINASE INHIBITORS

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of such as TrkA, TrkB, TrkC, Jak2, Jak3 and CK2, thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSYNE KINASES

Compounds of formula (I): and their use in the inhibition of Trk activity are described.

3-(heteroarylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.