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150780-67-9

5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite, also known as 2''-OMe-ibu-G Phosphoramidite, is a chemical compound used in the field of molecular biology and biochemistry. It is characterized by its unique structure, which includes a 5'-O-(4,4-Dimethoxytrityl) group, a 2'-O-methyl modification, an N-isobutyrylguanosine moiety, and a 3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite group. 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite plays a crucial role in the synthesis of native-like crosslinked duplex RNA through interstrand crosslinking reactions.

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  • (2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2-ISOBUTYRAMIDO-6-OXO-1H-PURIN-9(6H)-YL)-4-METHOXYTETRAHYDROFURAN-3-YL (2-CYANOETHYL) DIISOPROPYLPHOSPHORAMIDITE

    Cas No: 150780-67-9

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  • 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyroyl-2'-O-methylguanosine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]-phosphoramidite

    Cas No: 150780-67-9

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  • 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

    Cas No: 150780-67-9

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  • 150780-67-9 Structure

  • Basic information

    1. Product Name: 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
    2. Synonyms: 2’-O-Methy-rG(N-ibu)Phosphoramidite;N-blocked-5'-O-DMT-2'-O-Me CED guanosine phosphoramidite;5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite;5'-O-DMT-2'-O-Me-rG(N-iBu)-3'-CEDPA;2'-OMe-ibu-G Phosphoramidite;5'-O-DMT-2'-O-Me-G(ibu) phosporamidite;DMT-2′O-Methyl-rG(ib) Phosphoramidite;2'-O-Methyl-N2-Isobutyryl-5'-O-DMT-Guanosine-3'-CE-Phosphoramidite
    3. CAS NO:150780-67-9
    4. Molecular Formula: C45H56N7O9P
    5. Molecular Weight: 869.951
    6. EINECS: 2017-001-1
    7. Product Categories: N/A
    8. Mol File: 150780-67-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: white to off-white/
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly, Sonicated)
    9. PKA: 9.16±0.20(Predicted)
    10. CAS DataBase Reference: 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(150780-67-9)
    12. EPA Substance Registry System: 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(150780-67-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 150780-67-9(Hazardous Substances Data)

150780-67-9 Usage

Uses

Used in Molecular Biology and Biochemistry:
5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is used as a key building block for the synthesis of native-like crosslinked duplex RNA. The application reason is its ability to facilitate interstrand crosslinking reactions between vinylpurine on one strand and target cytosine or uracil on the opposite strand, resulting in the formation of stable and native-like duplex RNA structures.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is used as a synthetic intermediate for the development of novel RNA-based therapeutics. The application reason is its potential to enhance the stability, specificity, and efficacy of RNA molecules, which can be utilized in the treatment of various diseases, including cancer and genetic disorders.
Used in Research and Development:
5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is also used in research and development for the study of RNA structure, function, and interactions with other biomolecules. The application reason is its ability to provide insights into the molecular mechanisms underlying RNA biology and to contribute to the design of new RNA-based tools and technologies.

Check Digit Verification of cas no

The CAS Registry Mumber 150780-67-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,7,8 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 150780-67:
(8*1)+(7*5)+(6*0)+(5*7)+(4*8)+(3*0)+(2*6)+(1*7)=129
129 % 10 = 9
So 150780-67-9 is a valid CAS Registry Number.

150780-67-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name DMT-2′O-Methyl-rG(ib) Phosphoramidite

1.2 Other means of identification

Product number -
Other names 2'-OMe-ibu-GPhosphoramidite

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:150780-67-9 SDS

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