Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties
On the basis of the new finding that the protein synthesis inhibitor cycloheximide (1, 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6- piperidinedione) is able to competitively inhibit hFKBP12 (K1 = 3.4 μM) and homologous enzymes, a se