- Catalyst- and organic solvent-free synthesis of thioacids in water
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Thioacids and thioamino acids were synthesized in excellent yields from readily available acyl benzotriazoles and sodium hydrosulfide in water at room temperature. The new methodology features mild reaction conditions, high yields, short reaction times, and does not involve the use of organic solvents or bases. The reaction is eco-friendly, and the workup procedure is simple and does not require chromatographic separation.
- Elagawany, Mohamed,Hegazy, Lamees,Elgendy
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- Diacyl Disulfide: A Reagent for Chemoselective Acylation of Phenols Enabled by 4-(N,N-Dimethylamino)pyridine Catalysis
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A general and excellent acylation reagent, diacyl disulfide, was uncovered for efficient ester formation enabled by DMAP (4-(N,N-dimethylamino)pyridine) catalysis. This protocol offered a promising synthetic platform on site-selective acylation of phenolic and primary aliphatic hydroxyl groups, which greatly expanded the realm of protecting group chemistry. The importance of the reagent was also reflected by its excellent moisture tolerance, high efficiency, and potential in synthetic chemistry and biologically meaningful natural product modification.
- Liu, Hong-Xin,Dang, Ya-Qian,Yuan, Yun-Fei,Xu, Zhi-Fang,Qiu, Sheng-Xiang,Tan, Hai-Bo
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supporting information
p. 5584 - 5587
(2016/11/17)
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- A facile method for the synthesis of diacyl disulfides
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A facile method for the synthesis of diacyl disulfides is reported. Sulfur is reduced with samarium diiodide at room temperature to give samarium disulfides, which react with acyl chlorides in the presence of HMPA to afford the corresponding diacyl disulfides in high yields.
- Jia, Xue-Shun,Liu, Xiao-Tao,Li, Qing,Huang, Qing,Kong, Ling-Long
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p. 547 - 548
(2007/10/03)
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- Synthesis of diacyl disulfides using a polymer supported reagent
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Various diacyl disulfides are prepared easily in high yields from the corresponding acid chlorides under mild and non-aqueous conditions using a polymer supported reagent obtained from elemental sulfur and Amberlyst (OH)- . The polymeric reagent is regenerable.
- Tamami,Kiasat
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p. 1275 - 1280
(2007/10/03)
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- A convenient method for the synthesis of diacyl disulfides
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A simple and general method for the synthesis of diacyl disulfides is reported. Sulfur is allowed to react with sodium hydroxide to give sodium disulfide at 65°C under PTC, which can react with acyl halides to afford diacyl disulfides in good to excellent isolated yields. The effects of solvents and phase transfer catalysts are discussed.
- Wang,Cui,Hu,Zhao
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p. 889 - 898
(2007/10/02)
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