150990-60-6Relevant articles and documents
Multichannel-emissive V-shaped boryl-BODIPY dyads: Synthesis, structure, and remarkably diverse response toward fluoride
Swamy P, Chinna Ayya,Mukherjee, Sanjoy,Thilagar, Pakkirisamy
, p. 4813 - 4823 (2014)
Three new V-shaped boryl-BODIPY dyads (1-3) were synthesized and structurally characterized. Compounds 1-3 are structurally close molecular siblings differing only in the number of methyl substituents on the BODIPY moiety that were found to play a major role in determining their photophysical behavior. The dyads show rare forms of multiple-channel emission characteristics arising from different extents of electronic energy transfer (EET) processes between the two covalently linked fluorescent chromophores (borane and BODIPY units). Insights into the origin and nature of their emission behavior were gained from comparison with closely related model molecular systems and related photophysical investigations. Because of the presence of the Lewis acidic triarylborane moiety, the dyads function as highly selective and sensitive fluoride sensors with vastly different response behaviors. When fluoride binds to the tricoordinate borane center, dyad 1 shows gradual quenching of its BODIPY-dominated emission due to the ceasing of the (borane to BODIPY) EET process. Dyad 2 shows a ratiometric fluorescence response for fluoride ions. Dyad 3 forms fluoride-induced nanoaggregates that result in fast and effective quenching of its fluorescence intensity just for ~0.3 ppm of analyte (i.e., 0.1 equiv ≡ 0.26 ppm of fluoride). The small structural alterations in these three structurally close dyads (1-3) result in exceptionally versatile and unique photophysical behaviors and remarkably diverse responses toward a single analyte, i.e., fluoride ion.
A novel flavone-based fluorescent probe for relay recognition of HSO3- and Al3+
Xu, Shuai,Tang, Ruiren,Wang, Zhen,Zhou, Yin,Yan, Rui
, p. 208 - 215 (2015/05/20)
In this work, a new flavone-based fluorescent probe 3-hydroxy-3′-formylflavone (3HFF) was designed to achieve highly selective relay recognition of HSO3- and Al3+ in DMSO-H2O (2:8, v/v) solution. 3HFF displayed a highly selective response to HSO3- with a green fluorescence appearing at 524 nm. Moreover, the in situ generated 3HFF + HSO3- system demonstrated eminent relay recognition capability for Al3+ with a blue fluorescence appearing at 453 nm by the formation of a 1:1 complex between 3HFF and Al3+ in DMSO-H2O (2:8, v/v) solution. However, only slight change was observed in emission intensity with addition of Al3+ to 3HFF, and indicated HSO3- was essential for the sensing of Al3+. This work achieves the detection of HSO3- and Al3+ by only one probe and provides another example for this rare combination (anion/metal).
METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)
-
Page/Page column 143, (2011/11/01)
Provided herein are methods of treating cancer comprising administering a topoisomerase inhibitor, temozolomide, or a platin in combination with a Compound of Formula (I) or Formula (II), where the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein.
DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
-
Page/Page column 75, (2010/03/02)
A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.