- Nano cobalt ferrite catalyzed coupling reaction of nitroarene and alkyl halide: An odorless and ligand-free rout to unsymmetrical thioether synthesis
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This study describes an odorless protocol for the synthesis of unsymmetrical sulfides via cobalt ferrite (CoFe2O4) catalyzed cross-coupling reaction of nitroarenes with alkyl halides in the presence of thiourea as sulfur source under
- Moghaddam, Firouz Matloubi,Pourkaveh, Raheleh
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- Copper nanoparticles supported on 2-methoxy-1-phenylethanone-functionalized MCM-41: An efficient and recyclable catalyst for one-pot three-component C–S coupling reaction of aryl halides with benzyl bromide and thiourea
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An environmentally friendly copper-based catalyst supported on 2-methoxy-1-phenylethanone-functionalized MCM-41 was prepared and characterized by Fourier transform-infrared, transmission electron microscopy, field emission-scanning electron microscopy, X-ray diffraction and inductively coupled plasma techniques. The catalyst was applied for the one-pot three-component C–S coupling reactions of aryl halides with benzyl bromide and thiourea under aerobic conditions to afford the corresponding coupled products in good yields in water. The catalyst could be recovered and recycled five times. These results prove 2-methoxy-1-phenylethanone-functionalized MCM-41 supported Cu (II) complex was not leached during the reaction. Also it shows the correct heterogeneous nature of the catalyst.
- Hajipour, Abdol R.,Fakhari, Farzaneh,Bidhendi, Gholamreza Nabi
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- Metal acetylacetonates covalently anchored onto amine functionalized silica/starch composite for the one-pot thioetherification and synthesis of 2H-indazoles
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This paper reports a series of novel metal acetylacetonates covalently anchored onto amine functionalized silica/starch composite, prepared by the Schiff condensation of metal acetylacetonates [Co(acac)2, Cu(acac)2, Pd(acac)2, Ru(acac)3, Mn(acac)3, Co(acac)3] with organically modified 3-aminopropyl silica/starch composite. Different metal acetylacetonates have been chosen with a view to select the most active heterogeneous catalyst. Among various catalysts, covalently anchored Cu(acac)2 onto amine functionalized silica/starch composite [ASS-Cu(acac)2] was found to be the most active and recyclable catalyst for the one-pot thioetherification and one-pot three component synthesis of 2H-indazoles via consecutive C-N and N-N bond formations. All the catalysts were characterized by FTIR, TGA and AAS analysis and the most active catalyst, [ASS-Cu(acac)2] was further characterized by SEM and TEM. The catalyst could be recovered by simple filtration and reused with almost consistent activity for four consecutive runs.
- Sodhi, Ravinderpal Kour,Changotra, Avtar,Paul, Satya
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- Nanolayered cobalt-molybdenum sulphides (Co-Mo-S) catalyse borrowing hydrogen C-S bond formation reactions of thiols or H2S with alcohols
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Nanolayered cobalt-molybdenum sulphide (Co-Mo-S) materials have been established as excellent catalysts for C-S bond construction. These catalysts allow for the preparation of a broad range of thioethers in good to excellent yields from structurally diverse thiols and readily available primary as well as secondary alcohols. Chemoselectivity in the presence of sensitive groups such as double bonds, nitriles, carboxylic esters and halogens has been demonstrated. It is also shown that the reaction takes place through a hydrogen-autotransfer (borrowing hydrogen) mechanism that involves Co-Mo-S-mediated dehydrogenation and hydrogenation reactions. A novel catalytic protocol based on the thioetherification of alcohols with hydrogen sulphide (H2S) to furnish symmetrical thioethers has also been developed using these earth-abundant metal-based sulphide catalysts.
- Corma, Avelino,Sorribes, Iván
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p. 3130 - 3142
(2019/03/13)
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- Electrochemically Promoted Nickel-Catalyzed Carbon-Sulfur Bond Formation
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This work describes a nickel-catalyzed Ullmann-type thiolation of aryl iodidesunder mild electrochemical conditions. The simple undivided cell with graphene/nickel foam electrode setups offers excellent substrate tolerance, affording aryl and alkyl sulfides in good chemical yields. Furthermore, the mechanism for this electrochemical cross-coupling reaction has been investigated by cyclic voltammetry.
- Wang, Yang,Deng, Lingling,Wang, Xiaochen,Wu, Zhengguang,Wang, Yi,Pan, Yi
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p. 1630 - 1634
(2019/03/08)
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- Photochemical, Metal-Free Sigmatropic Rearrangement Reactions of Sulfur Ylides
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Sigmatropic rearrangement reactions constitute one of the most fundamental reactions of carbenes. While state-of-the-art synthetic methods require the use of expensive precious metal catalysts, the application of visible light for the photolysis of α-aryldiazoacetates is much less investigated and provides an operationally simple entry to carbenes under mild reaction conditions. Herein, we report on blue-light induced sigmatropic rearrangement reactions of sulfur compounds with α-aryldiazoacetates. This process, depending on the substitution pattern of the sulfide, opens up formal insertion reactions of carbenes into S?N, S?C, or C?H bonds.
- Yang, Zhen,Guo, Yujing,Koenigs, Rene M.
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supporting information
p. 6703 - 6706
(2019/05/10)
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- HETEROCYCLIC COMPOUNDS WITH AN ROR(GAMMA)T MODULATING ACTIVITY
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The present invention relates to a compound that may have an ROR(gamma)t modulating activity and can thus be useful in the treatment of cancer.
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Paragraph 0604
(2018/03/06)
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- Visible-Light-Mediated Synthesis of Unsymmetrical Diaryl Sulfides via Oxidative Coupling of Arylhydrazine with Thiol
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A metal-free visible-light-promoted oxidative coupling between thiols and arylhydrazines has been developed to afford diaryl sulfides using a catalytic amount of rose bengal as photocatalyst under aerobic conditions. A library of unsymmetrical diaryl sulfides with broad functionalities was synthesized in good yields at room temperature. The present methodology is also applicable to benzo[d]thiazole-2-thiols, benzo[d]oxazole-2-thiol, 1H-benzo[d]imidazole-2-thiols, and 1H-imidazole-2-thiol.
- Kibriya, Golam,Mondal, Susmita,Hajra, Alakananda
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supporting information
p. 7740 - 7743
(2018/12/14)
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- Aryl alkyl, aryl aryl thioether compound and its synthesis method
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The invention discloses a synthesis method of an aryl-alkyl and aryl-aryl thioether compound represented by a formula (III). According to the synthesis method, aryl tetrafluoroboric acid diazonium salt is taken as a reaction raw material in a reaction solvent, aryl and alkyl thiosulfate is taken as a sulfurizing agent, and the materials react under the catalysis action of visible light and a photosensitive agent to obtain the aryl-alkyl and aryl-aryl thioether compound. According to the synthesis method, the raw materials are easy to obtain and are cheap, the reaction operation is simple, the reaction condition is mild and environment-friendly, the yield is higher, the functional group tolerance is excellent, later modification of drugs is successfully realized, and an efficient C-S bond construction method is provided for medicinal chemistry and biological orthogonal chemistry research.
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Paragraph 0051-0054
(2017/08/16)
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- CuI promoted sulfenylation of organozinc reagents with arylsulfonyl chlorides
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A CuI promoted sulfenylation of organozinc reagents with arylsulfonyl chlorides/PPh3 has been explored. This reaction proceeded smoothly through an alkyl/aryl radical (generated from organometallics) under mild conditions and produced the desired sulfide products in excellent yields.
- Fu, Ying,Su, Yuhu,Xu, Qin-Shan,Du, Zhengyin,Hu, Yulai,Wang, Ke-Hu,Huang, Danfeng
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p. 6018 - 6022
(2017/02/05)
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- Sulfonyl halide synthesis by thiol oxyhalogenation using NBS/NCS – iPrOH
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A rapid and facile method provides a general route to sulfonyl bromides/chlorides by the oxidation of thiols using NXS – ROH (X?=?Br,Cl, R?=?iPr) as an oxyhalogenation reagent. Control experiments suggest that the alcohol component is the source of oxygen. The proposed method enable the access to structurally diverse sulfonyl bromides and chlorides including challenging examples, inaccessible by other synthetic methods.
- Silva-Cuevas, Carolina,Perez-Arrieta, Carlos,Polindara-García, Luis A.,Lujan-Montelongo, J. Armando
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supporting information
p. 2244 - 2247
(2017/05/16)
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- Versatile C(sp2)?C(sp3) Ligand Couplings of Sulfoxides for the Enantioselective Synthesis of Diarylalkanes
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The reaction of chiral (hetero)aryl benzyl sulfoxides with Grignard reagents affords enantiomerically pure diarylalkanes in up to 98 % yield and greater than 99.5 % enantiomeric excess. This ligand coupling reaction is tolerant to multiple substitution patterns and provides access to diverse areas of chemical space in three operationally simple steps from commercially available reagents. This strategy provides orthogonal access to electron-deficient heteroaromatic compounds, which are traditionally synthesized by transition metal catalyzed cross-couplings, and circumvents common issues associated with proto-demetalation and β-hydride elimination.
- Dean, William M.,?iau?iulis, Mindaugas,Storr, Thomas E.,Lewis, William,Stockman, Robert A.
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supporting information
p. 10013 - 10016
(2016/08/16)
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- Functionalized graphene oxide as an efficient adsorbent for CO2 capture and support for heterogeneous catalysis
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We have designed new imine-functionalized graphene oxide (IFGO) through post synthetic modifications involving co-condensation of 3-aminopropyltriethoxysilane with graphene oxide basal plane containing hydroxyl and epoxy functional groups, followed by Schiff base condensation reaction with 2,6-diformyl-4-methylphenol and impregnation of copper(ii) to it through covalent attachment (Cu-IFGO). Powder X-ray diffraction, N2 sorption analysis, FT-IR, HR-TEM, FE-SEM and TGA/DTA analysis are employed to characterize the materials. The IFGO material exhibits good CO2 storage capacity of 8.10 mmol g-1 (35.64 wt%) and 2.10 mmol g-1 (9.24 wt%) at 273 K and 298 K temperature, respectively, up to 3 bar pressure, suggesting its potential application in environmental clean-up. Also, Cu-IFGO showed high catalytic activity in microwave-assisted one-pot three-component C-S coupling reactions for a diverse range of aryl halides with thiourea and benzyl bromide in aqueous medium to obtain aryl thioether products (maximum yield 86%), which are derivatives of natural products. Moreover, having imine and hydroxyl groups in functionalized graphene oxide, the grafted Cu(ii) chelated at the graphene oxide surface so strongly that it could not be leached out from the material during the course of the coupling reaction. Thus, it displayed very small decrease in product yield up to the sixth reaction cycle suggesting a sustainable future of this Cu(ii)-grafted catalyst.
- Bhanja, Piyali,Das, Sabuj Kanti,Patra, Astam K.,Bhaumik, Asim
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p. 72055 - 72068
(2016/08/09)
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- A new Cu-anchored mesoporous organosilica material for facile C-S coupling reactions under microwave irradiation
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We report a new ordered Cu-anchored 2D-hexagonal mesoporous imine functionalized organosilica material Cu-MPIOS. This Cu-anchored mesoporous material has been synthesized via post synthetic functionalization of SBA-15 with 3-(2-aminoethylamino)propyl-dimethoxymethylsilane followed by Schiff-base condensation with 2-thiophene carboxaldehyde. Cu(I) has been grafted finally over Schiff-base functionalized mesoporous material through chemical impregnation to obtain Cu-MPIOS. The materials are characterized thoroughly using various techniques like powder X-ray diffraction, N2 adsorption/desorption analysis, FTIR, UV-vis spectroscopy, FEG-TEM, FE-SEM, 13C cross-polarization magic angle spinning NMR, TGA/DTA, EPR, AAS and CHN chemical analysis. High Brunauer-Emmett-Teller (BET) surface area and the presence of very large size mesopores (8.1 nm) in Cu-MPIOS has motivated us to explore its catalytic activity in one-pot three-component C-S cross coupling reaction by varying different aryl halides in the aqueous medium under microwave assisted heating conditions. This heterogeneous Cu-catalyst shows high catalytic performance as well as good recycling efficiency in this C-S coupling reaction, suggesting its future potential for the synthesis of value added thioether derivatives.
- Bhanja, Piyali,Gomes, Ruth,Satyanarayana, Lanka,Bhaumik, Asim
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p. 104 - 112
(2016/02/18)
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- An aryl alkyl thioether compound and its synthetic method
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The invention discloses a synthetic method of an aryl alkyl thioether compound shown as formula (II), and the synthetic method is as follows: at room temperature and in a water phase, using triazene and haloalkane as reaction raw materials, using Na2S2O3 as a vulcanization reagent for reaction under the promotion effect of a copper catalyst and a Lewis acid to obtain the aryl alkyl thioether compound. The advantages of the synthetic method are as follows: reaction is efficient and yield is high; the vulcanization reagent is cheap, easy to obtain, stable, and free of irritating smell; the reaction is carried out in the solvent green water, the reaction is free of addition of a phase transfer catalyst and a volatile organic solvent, and is environmentally friendly; the reaction is carried out at room temperature, is mild in condition; the catalyst copper sulfate used in the reaction is cheap and economic reaction; the reaction substrate is easy in preparation; after amplification, the reaction efficiency is higher.
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Paragraph 0114-0117
(2019/02/04)
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- Mechanistic Study of a Photocatalyzed C-S Bond Formation Involving Alkyl/Aryl Thiosulfate
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This study presents thioether construction involving alkyl/aryl thiosulfates and diazonium salt catalyzed by visible-light-excited [Ru(bpy)3Cl2] at room temperature in 44-86 % yield. Electron paramagnetic resonance studies found that thiosulfate radical formation was promoted by K2CO3. Conversely, radicals generated from BnSH or BnSSBn (Bn=benzyl) were clearly suppressed, demonstrating the special property of thiosulfate in this system. Transient absorption spectra confirmed the electron-transfer process between [Ru(bpy)3Cl2] and 4-MeO-phenyl diazonium salt, which occurred with a rate constant of 1.69×109 M-1 s-1. The corresponding radical trapping product was confirmed by X-ray diffraction. The full reaction mechanism was determined together with emission quenching data. Furthermore, this system efficiently avoided the over-oxidation of sulfide caused by H2O in the photoexcited system containing Ru2+. Both aryl and heteroaryl diazonium salts with various electronic properties were investigated for synthetic compatibility. Both alkyl- and aryl-substituted thiosulfates could be used as substrates. Notably, pharmaceutical derivatives afforded late-stage sulfuration smoothly under mild conditions.
- Li, Yiming,Xie, Weisi,Jiang, Xuefeng
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supporting information
p. 16059 - 16065
(2015/11/03)
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- An efficient iron-catalyzed S-arylation of aryl and alkylthiols with aryl halides in the presence of water under aerobic conditions
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Abstract In this study, an environmentally benign FeCl3·6H2O/l-proline catalytic system in the presence of TBAB was employed as a catalyst for the coupling reactions of aryl halides with aryl and alkyl thiols in water under aerobic conditions. The versatility, low cost, and environmental friendliness, in combination with high yields, makes the procedure noteworthy. This protocol offers a simple and efficient thioetherification method for aryl halides.
- Sindhu,Thankachan, Amrutha P.,Thomas, Anns Maria,Anilkumar, Gopinathan
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supporting information
p. 4923 - 4926
(2015/07/28)
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- A novel and efficient zinc-catalyzed thioetherification of aryl halides
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The first zinc-catalysed protocol for the C-S cross-coupling reaction is reported. Zinc catalysis has an undeniable advantage over other catalytic systems as it is non-toxic, and the catalysts are easily available and cheap, with environmentally benign properties. This novel, efficient, palladium- and triphenylphosphine-free protocol yielded a variety of aryl and alkyl sulfides in moderate to excellent yields. This journal is
- Thankachan, Amrutha P.,Sindhu,Krishnan, K. Keerthi,Anilkumar, Gopinathan
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p. 32675 - 32678
(2015/04/27)
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- Novel heterogeneous catalyst systems based on Pd(0) nanoparticles onto amine functionalized silica-cellulose substrates [Pd(0)-EDA/SCs]: Synthesis, characterization and catalytic activity toward C-C and C-S coupling reactions in water under limiting basic conditions
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Novel heterogeneous catalyst systems based on the immobilization of Pd(0) nanoparticles onto ethylene diamine functionalized silica-cellulose substrates [Pd(0)-EDA/SCs] are reported with a view to introduce new synthetic routes under base-free conditions. The base functionalized organic/inorganic hybrid provides specific basic sites for the reactions to occur under base-free or less basic conditions, and that too with excellent yields. Moreover, the basic nitrogen sites present on the substrate can effectively stabilize and enhance the activity of Pd(0) nanoparticles by preventing their agglomeration and controlling their size. All the catalysts were characterized by TGA and FTIR analysis and the most active catalyst, [Pd(0)-EDA/SC-2] was further characterized by SEM, TEM, HRTEM, EDX, CHN and XRD studies. Additionally, it is shown that the Pd(0)-EDA/SCs exhibits excellent activity under limiting basic conditions for the C-C and C-S coupling reactions employing water as the "Green solvent". Furthermore, the novel catalyst could be recovered in a facile manner from the reaction mixture and could be reused up to five times without significant loss of catalytic activity.
- Bhardwaj, Madhvi,Sahi, Seema,Mahajan, Hitesh,Paul, Satya,Clark, James. H.
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- Sulfide synthesis through copper-catalyzed C-S bond formation under biomolecule-compatible conditions
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We report here an efficient and mild method for constructing C-S bonds. The reactions were carried out with Na2S2O3 as a sulfurating reagent, CuSO4 as a catalyst, and water as solvent without any surfactant. The products were achieved in moderate to excellent yields at room temperature under air. Notably, this reaction is compatible with various biomolecules including amino acids, oligosaccharides, nucleosides, proteins, and cell lysates. This journal is
- Zhang, Yonghong,Li, Yiming,Zhang, Xiaomei,Jiang, Xuefeng
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p. 941 - 944
(2015/01/09)
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- Cu-grafted functionalized mesoporous SBA-15: A novel heterogeneous catalyst for facile one-pot three-component C-S cross-coupling reaction of aryl halides in water
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A highly ordered 2D hexagonal Cu-grafted functionalized mesoporous SBA-15 (Cu-PIF-SBA-15) has been designed through postsynthetic modification of mesoporous SBA-15. Surface functionalization technique has been employed to synthesize-NH2 functionalized mesoporous SBA-15 material. Schiff base condensation of this-NH2 functionalized SBA-15 with phloroglucinol dialdehyde leads to the formation of PIF-SBA-15. Reaction of PIF-SBA-15 with Cu(OAc)2·H2O in ethanol under reflux leads to the formation of Cu-PIF-SBA-15 catalyst. This Cu-PIF-SBA-15 catalyst exhibits excellent catalytic activity in a one-pot three-component C-S coupling reaction for a diverse range of aryl halides (bromide and chloride) with thiourea and benzyl bromide in aqueous medium to offer aryl alkyl thioether in very good yields. Due to the strong binding ability of the imine-N and phenolic-OH functional groups present in the phloroglucinol diimine moiety of the framework, the anchored Cu(II) could not leach out from the surface of the mesoporous catalyst during the course of reaction, and it has been observed that six repetitive reaction cycles could not cause any appreciable loss in the catalytic activity of this material.
- Mondal, John,Borah, Parijat,Modak, Arindam,Zhao, Yanli,Bhaumik, Asim
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p. 257 - 265
(2014/05/20)
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- A highly efficient Cu-catalyzed S-transfer reaction: From amine to sulfide
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A highly efficient Cu-catalyzed dual C-S bonds formation reaction, proceeding in alcohol and water under air, is reported, in which inodorous stable Na2S2O3 is used as a sulfurating reagent. This powerful strategy provides a practical and efficient approach to construct thioethers, using readily available aromatic amines and alkyl halides as starting materials. Sensitive and synthetic useful functional groups could be tolerated. Furthermore, pharmaceuticals, glucose, an amino acid, and a chiral ligand are successfully furnished by this late-stage sulfuration strategy.
- Li, Yiming,Pu, Jiahua,Jiang, Xuefeng
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supporting information
p. 2692 - 2695
(2014/06/09)
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- Palladium nanoparticles supported on silica diphenylphosphinite as efficient catalyst for C-O and C-S arylation of aryl halides
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Silica diphenylphosphinite (SDPP) can be easily obtained through direct phosphorylation of silica gel. Further reaction of SDPP with Pd(II) produces nano Pd(0)/SDPP. This nano Pd(0) catalyst exhibits excellent reactivity for the C-O and C-S arylation of different aryl iodides, bromides and chloride with phenols and thiophenols. This heterogeneous catalyst shows excellent recyclability and can be easily recovered and reused for several runs. Copyright
- Iranpoor, Nasser,Firouzabadi, Habib,Rostami, Abed
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p. 501 - 506
(2013/09/23)
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- A highly efficient palladium-catalyzed one-pot synthesis of unsymmetrical aryl alkyl thioethers under mild conditions in water
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A palladium-catalyzed, one-pot synthesis of unsymmetrical aryl alkyl thioethers involving aryl halides (aryl bromides and chlorides), thiourea and alkyl bromides has been realized under mild conditions (room temperature to 50 °C) in water with polyoxyethanyl α-tocopheryl sebacate (PTS) as amphiphile. The PTS/water could be recycled in up to eight runs without an obvious change in its activity. Copyright
- Wang, Liang,Zhou, Wei-You,Chen, Sheng-Chun,He, Ming-Yang,Chen, Qun
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supporting information; experimental part
p. 839 - 845
(2012/05/20)
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- One-pot thioetherification of aryl halides with thiourea and benzyl bromide in water catalyzed by Cu-grafted furfural imine-functionalized mesoporous SBA-15
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Surface functionalization of SBA-15 followed by its reaction with Cu(OAc)2 has been carried out to develop a new Cu-grafted functionalized mesoporous material, which catalyzes one-pot three component coupling of different aryl halides with thiourea and benzyl bromide in aqueous medium to produce aryl thioethers in very good yields (80-88%).
- Mondal, John,Modak, Arindam,Dutta, Arghya,Basu, Sohini,Jha,Bhattacharyya, Dibyendu,Bhaumik, Asim
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supporting information; experimental part
p. 8000 - 8002
(2012/09/08)
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- Efficient nickel/N-heterocyclic carbene catalyzed C-S cross-coupling
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The cross-coupling reaction of aryl halides with aliphatic and aromatic thiols catalyzed by readily available Ni(OAc)2 with N-heterocyclic carbene (NHC) is reported. Ni(OAc)2/NHC catalyst showed good activities toward various aryl halides in C-S coupling reaction, even with aryl chlorides. Reactions occurred in excellent yields, broad scope, and high tolerance of functional groups.
- Guan, Pei,Cao, Changsheng,Liu, Yun,Li, Yunfei,He, Pan,Chen, Qian,Liu, Gang,Shi, Yanhui
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supporting information
p. 5987 - 5992,6
(2012/12/12)
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- Efficient nickel/N-heterocyclic carbene catalyzed C-S cross-coupling
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The cross-coupling reaction of aryl halides with aliphatic and aromatic thiols catalyzed by readily available Ni(OAc)2 with N-heterocyclic carbene (NHC) is reported. Ni(OAc)2/NHC catalyst showed good activities toward various aryl halides in C-S coupling reaction, even with aryl chlorides. Reactions occurred in excellent yields, broad scope, and high tolerance of functional groups.
- Guan, Pei,Cao, Changsheng,Liu, Yun,Li, Yunfei,He, Pan,Chen, Qian,Liu, Gang,Shi, Yanhui
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supporting information
p. 5987 - 5992
(2013/01/13)
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- Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B
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It has recently been reported that nitrile containing compounds frequently act as potent monoamine oxidase B (MAO-B) inhibitors. Modelling studies suggest that this high potency inhibition may rely, at least in part, on polar interactions between nitrile functional groups and polar moieties within the MAO-B substrate cavity. In an attempt to identify potent and selective inhibitors of MAO-B and to contribute to the known structure-activity relationships of MAO inhibition by nitrile containing compounds, the present study examined the MAO inhibitory properties of series of novel sulfanylphthalonitriles and sulfanylbenzonitriles. The results document that the evaluated compounds are potent and selective MAO-B inhibitors with most homologues possessing IC50 values in the nanomolar range. In general, the sulfanylphthalonitriles exhibited higher binding affinities for MAO-B than the corresponding sulfanylbenzonitrile homologues. Among the compounds evaluated, 4-[(4-bromobenzyl)sulfanyl]phthalonitrile is a particularly promising inhibitor since it displayed a high degree of selectivity (8720-fold) for MAO-B over MAO-A, and potent MAO-B inhibition (IC50 = 0.025 μM). Based on these observations, this structure may serve as a lead for the development of therapies for neurodegenerative disorders such as Parkinson's disease.
- Van Der Walt, Mietha M.,Terre'Blanche, Gisella,Lourens, Anna C.U.,Petzer, Anél,Petzer, Jacobus P.
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supporting information
p. 7367 - 7370
(2013/02/21)
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- SUBSTITUTED ARYLSULFONAMIDES AS ANTIVIRAL AGENTS
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The invention relates to substituted arylsulfonamides of formula (I) and methods for their preparation as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particu
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Page/Page column 10
(2009/07/18)
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- Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
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The present invention relates to derivatives of the formula the process for their preparation, and to their uses in therapeutics, especially as drugs with anti-inflammatory, analgesic and chemopreventive properties.
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- 1,2-diarylmethylene derivatives, their methods of preparation and their uses in therapeutics
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The present invention relates to the derivatives of formula: STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
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- A biomimetic methyl transfer from amine to thiol
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A biomimetic methyl transfer, analogous to a tetrahydrofolate-to-homocystein transfer, is simulated by the reaction of methylammonium salts with arylthiolatocobaloxime; the mechanism proposed is an electron transfer from the cobaloxime to the ammonium ion followed by radical substitution of the methyl group.
- Tada, Masaru,Kambe, Tohru,Inouye, Yoshinobu
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- 1,2 diarylmethylene derivatives, their methods of preparation and their uses in therapeutics
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The present invention relates to the derivatives of formula: STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
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- Diarylmethylidenefuran derivatives and their uses in therapeutics
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The present invention relates to the derivatives of the formula STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
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- Carbocyclic diarylmethylene derivatives, processes for their preparation and their uses in therapeutics
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The present invention relates to the carbocyclic diarylmethylene derivatives of formula (I): STR1 and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.
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