151012-17-8

Basic information

• Product Name: BOC-MELYS(2-CL-Z)-OH
• Synonyms: BOC-L-MELYS(2CL-Z)-OH;BOC-N-ALPHA-METHYL-N-EPSILON-2-CHLOROBENZYLOXYCARBONYL-L-LYSINE;BOC-MELYS(2-CL-Z)-OH;N-ALPHA-(T-BUTYLOXYCARBONYL)-N-ALPHA-METHYL-N-EPSILON-(2-CHLOROBENZYLOXYCARBONYL)-L-LYSINE;Boc-Nalpha-methyl-Ne-2-chlorobenzyl-oxycarbonyl-L-lysine
• CAS NO: 151012-17-8
• Molecular Formula: C₂₀H₂₉ClN₂O₆
• Molecular Weight: 428.91
• Mol File: 151012-17-8.mol

Chemical Properties

• Boiling Point: 587.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.224±0.06 g/cm3(Predicted)
• PKA: 4.01±0.21(Predicted)
• CAS DataBase Reference: BOC-MELYS(2-CL-Z)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-MELYS(2-CL-Z)-OH(151012-17-8)
• EPA Substance Registry System: BOC-MELYS(2-CL-Z)-OH(151012-17-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 151012-17-8(Hazardous Substances Data)

Upstream product

• 151012-16-7 N^α-(tert-butoxycarbonyl)-N^α-methyl-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 191939-74-9 (S)-6-(2-Chloro-benzyloxycarbonylamino)-2-methylamino-hexanoic acid tert-butyl ester 
• 151012-19-0 tris(benzyloxycarbonyl)-L-arginyl-N^α-methyl-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysine 
• 151012-18-9 tris(benzyloxycarbonyl)-L-arginyl-N^α-methyl-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysine tert-butyl ester 

Relevant articles and documents

Stabilized analogs of thymopentin. 2. 1,2- and 3,4-ketomethylene pseudopeptides

In this second paper in a series of three studies of stable analogs of thymopentin (Arg1-Lys2-Asp3-Val4-Tyr5), the synthesis of analogs stablized at peptide bonds 1,2 and 3,4 via insertion of ketomethylene units is described. A tris(carbobenzyloxy)arginyl(k)norleucine pseudopeptide was synthesized and coupled to Asp-Val-Phe-resin units followed by HF cleavage to prepare Arg(k)Nle-Asp-Val-Phe analogs. Preparation of N-BOC Asp(k)Val and N- BOC Asp(k)Ala units followed by coupling to Phe- or Tyr-resin units provided resin-bound pseudotripeptide substrates for attachment of various arginyl dipeptides. Cleavage from the resin afforded 3,4-ketomethylene-stabilized pseudopeptide analogs of thymopentin. The Arg-Lys-Asp(k)Val-Phe and ArgLys- Asp(k)Val-Tyr analogs were more strongly bound to CEM cells than thymopentin itself. There was significant enhancement of stability in serum for the analogs, especially those containing Arg(k)Nle or Arg-NMeLys moieties at the 1,2-peptide bond.