- A new synthesis of N-substituted-1,2,3,4-tetrahydro-4-phenylisoquinolin-3-ones
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1,2,3,4-Tetrahydro-4-phenylisoquinolin-3-ones 3 are obtained from appropriate N,N-disubstituted phenylacetamides 1, using lead tetraacetate (LTA) as oxidant and Lewis or proton acids as cyclizing agents. The methods for this conversion could be one stage (method B or C), or two stages (method A). The latter method was particularly developed to explain the mechanism of the reaction.
- Coskun,Sumengen
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p. 1393 - 1402
(2007/10/02)
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